Cortical reactivations predict future sensory responses.
Cortical reactivations predict future sensory responses.
复制标题
皮质重新激活预测未来的感觉反应。
DOI：
10.1038/s41586-023-06810-1
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发表时间：
2024
期刊：
影响因子：
64.8
通讯作者：
Andermann,MarkL
中科院分区：
文献类型：
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作者：
Nguyen,NghiaD;Lutas,Andrew;Amsalem,Oren;Fernando,Jesseba;Ahn,AndyYoung-Eon;Hakim,Richard;Vergara,Josselyn;McMahon,Justin;Dimidschstein,Jordane;Sabatini,BernardoL;Andermann,MarkL
许多离线记忆巩固理论认为，在显着的感觉体验期间激活的神经元模式将被忠实地重新激活，从而稳定该模式。然而，感官诱发的模式并不稳定，而是会随着重复的经历而漂移，, –。在这里，为了研究重新激活与感觉表征漂移之间的关系，我们对小鼠外侧视觉皮层中数千个兴奋性神经元的钙活动进行了成像。在视觉刺激后的一分钟内，我们观察到短暂的、刺激特异性的重新激活，通常伴有海马尖波波纹。在先前的刺激过程中，刺激特异性的再激活被局部皮质沉默所消除。会议早期的重新激活系统地不同于先前刺激引起的模式——它们更类似于未来的刺激反应模式，从而预测日内和跨日的代表性漂移。特别是，与刺激反应模式相比，更多或更少参与早期刺激再激活的神经元分别逐渐增加或减少其未来的刺激反应。事实上，我们可以仅使用重新激活的速率和内容来准确预测刺激反应的未来变化以及对不同刺激的反应的分离。因此，重新激活可能有助于感觉皮层反应模式的逐渐漂移和分离，从而增强感觉辨别力。
Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern,. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences, , –. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium activity of thousands of excitatory neurons in the mouse lateral visual cortex. During the minute after a visual stimulus, we observed transient, stimulus-specific reactivations, often coupled with hippocampal sharp-wave ripples. Stimulus-specific reactivations were abolished by local cortical silencing during the preceding stimulus. Reactivations early in a session systematically differed from the pattern evoked by the previous stimulus—they were more similar to future stimulus response patterns, thereby predicting both within-day and across-day representational drift. In particular, neurons that participated proportionally more or less in early stimulus reactivations than in stimulus response patterns gradually increased or decreased their future stimulus responses, respectively. Indeed, we could accurately predict future changes in stimulus responses and the separation of responses to distinct stimuli using only the rate and content of reactivations. Thus, reactivations may contribute to a gradual drift and separation in sensory cortical response patterns, thereby enhancing sensory discrimination.