Beneficial and adverse effects of chemopreventive agents
Beneficial and adverse effects of chemopreventive agents
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DOI：
10.1016/s0027-5107(02)00342-1
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发表时间：
2003-02-01
影响因子：
2.3
通讯作者：
Park, KK
中科院分区：
文献类型：
--
作者：
Lee, BM;Park, KK
本文综述了维生素A、维生素C、维生素E、β-胡萝卜素、吲哚-3-甲醇、辣椒素、大蒜、芦荟等化学预防剂的作用和副作用。两项以肺癌为终点的大型随机试验，α-生育酚，β-胡萝卜素（ATBC）预防研究和β-胡萝卜素和视黄醇功效试验（CARET），表明抗氧化剂可能对吸烟者有害。然而，林县研究和ATBC或CARET研究的结果在这方面存在显著差异，因此，抗氧化剂和致癌作用之间的关系仍然存在争议。吲哚-3-甲醇在结肠、甲状腺、胰腺和肝脏中具有促癌活性，而辣椒素改变化学致癌物的代谢，并可能在高剂量下促进致癌作用。大蒜中的有机硫化合物和硒对促癌期无或有一定的促进作用。尽管某些人类癌症的原因和性质是已知的，但关于抑制癌发生的化学预防机制的信息是不完善的。因此，明确的预防指南应仔细提供各种类型的肿瘤，适当考虑种族差异，和化学预防剂的有效性和安全性。(C)2002 Elsevier Science B. V.保留所有权利。
The beneficial and adverse effects of some chemopreventive agents, such as Vitamins A, C, E, beta-carotene, indole-3-carbinol, capsaicin, garlic, and aloe are reviewed. Two large randomized trials with a lung cancer endpoint, the Alpha-Tocopherol, Beta-Carotene (ATBC) Prevention Study and the Beta-Carotene and Retinol Efficacy Trial (CARET), suggested that antioxidants might be harmful in smokers. However, the results of the Linxian study and of the ATBC or the CARET studies were significantly different in this respect, and therefore, the relationship between antioxidant and carcinogenesis remains open to debate. Indole-3-carbinol has cancer promoting activities in the colon, thyroid, pancreas, and liver, whereas capsaicin alters the metabolism of chemical carcinogens and may promote carcinogenesis at high doses. Organosulfur compounds and selenium from garlic have no or a little enhancing effect on cancer promotion stage. Information upon chemopreventive mechanisms that inhibit carcinogenesis is imperfect, although the causes and natures of certain human cancers are known. Therefore, definitive preventive guidelines should be carefully offered for various types of tumors, which properly consider ethnic variations, and the efficacies and the safety of chemopreventive agents. (C) 2002 Elsevier Science B.V. All rights reserved.