BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: Differential relationship to global perfusion
BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: Differential relationship to global perfusion
复制标题
DOI：
10.1097/01.wcb.0000071887.63724.b2
复制
发表时间：
2003-07-01
影响因子：
6.3
通讯作者：
Buxton, RB
中科院分区：
文献类型：
--
作者：
Brown, GG;Zorrilla, LTE;Buxton, RB
作者研究了改变整体脑血流对血氧水平依赖性（BOLD）反应和手指拇指并置的灌注反应的影响。使用 PICORE/QUIPSS II 协议在八个手指-拇指并置试验中收集交错的粗体加权和灌注加权图像。受试者在无药物日以及第二次和第三次试验之间施用乙酰唑胺的当天进行研究。施用乙酰唑胺后，静息皮质灌注比施用前水平平均增加 20%，而 S1M1 手部区域对手指-拇指并置的 BOLD 反应平均下降 35%。与脑血管储备耗尽假说和氧限制模型的预测相反，没有观察到乙酰唑胺对 SIMI 手部区域脑血流反应的影响。在乙酰唑胺试验中，个体受试者数据的 BOLD 反应与静息皮质灌注呈负相关。这些结果表明，静息灌注会影响 BOLD 反应的强度，因此是功能磁共振成像研究中的一个重要混杂因素，并且响应乙酰唑胺给药而增加脑血流量的生理系统和响应神经活动改变而增加脑血流量的系统似乎具有累加效应。
The authors studied the effects of altering global cerebral blood flow on both blood oxygen level-dependent (BOLD) response and perfusion response to finger-thumb apposition. A PICORE/QUIPSS II protocol was used to collect interleaved BOLD-weighted and perfusion-weighted images on eight finger-thumb apposition trials. Subjects were studied on a drug-free day and on a day when acetazolamide was administered between the second and third trials. After acetazolamide administration, resting cortical per-fusion increased an average of 20% from preadministration levels, whereas the BOLD response to finger-thumb apposition decreased by an average of 35% in the S1M1 hand area. Contrary to predictions from the exhausted cerebrovascular reserve hypothesis and the oxygen limitation model, an effect of acetazolamide on cerebral blood flow response in the S I M I hand area was not observed. Across the acetazolamide trials, BOLD response was inversely correlated with resting cortical perfusion for individual subject data. These results suggest that resting perfusion affects the magnitude of the BOLD response and is thus an important confounding factor in fMRI studies, and that the physiologic systems that increase cerebral blood flow in response to acetazolamide administration and systems that increase cerebral blood flow in response to altered neural activity appear to have additive effects.