Amphiphilic Rhodamine Nano-assembly as a Type I Supramolecular Photosensitizer for Photodynamic Therapy
Amphiphilic Rhodamine Nano-assembly as a Type I Supramolecular Photosensitizer for Photodynamic Therapy
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DOI：
10.1021/acsanm.2c03192
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发表时间：
2022-10-09
影响因子：
5.9
通讯作者：
Kida, Toshiyuki
中科院分区：
文献类型：
--
作者：
Shigemitsu, Hajime;Sato, Kazuhide;Kida, Toshiyuki
光动力疗法（PDT）是一种很有前途的治疗多种癌症的临床方法。近年来，采用I型光敏剂（ps）的PDT由于在缺氧条件下进行高效PDT的可行性而引起了广泛的关注。特别是，I型超分子ps （SPSs）由于其易于杂交的功能可扩展性而成为有希望的候选者。但是，I型SPSs数量较少，发展战略尚未确立。在这项工作中，我们证明了一种简单的两亲性罗丹明19 （Rh19-MA-C18）的超分子组装具有I型SPS的功能，并对癌细胞和患癌小鼠表现出显著的PDT效应。这项工作证明了由两亲罗丹明染料组成的超分子纳米组件作为一种高效的I型SPS的潜力。
Photodynamic therapy (PDT) is a promising clinical method for treating a wide range of cancers. Recently, PDT employing type I photosensitizers (PSs) has attracted considerable attention owing to the feasibility of efficient PDT under hypoxic conditions. Particularly, type I supramolecular PSs (SPSs) are promising candidates owing to their functional extensibility by facile hybridization. However, type I SPSs are rare, and the development strategy has not been established yet. In this work, we demonstrated that supramolecular assembly of a simple amphiphilic rhodamine 19 (Rh19-MA-C18) functioned as a type I SPS and exhibited significant PDT effect on cancer cells and cancer-bearing mice. This work demonstrates the potential of supramolecular nano-assembly composed of an amphiphilic rhodamine dye as an efficient type I SPS.