Can bioactivity be tested in vitro with SBF solution?
Can bioactivity be tested in vitro with SBF solution?
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DOI：
10.1016/j.biomaterials.2009.01.008
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发表时间：
2009-04-01
期刊：
影响因子：
14
通讯作者：
Lemaitre, Jacques
中科院分区：
文献类型：
--
作者：
Bohner, Marc;Lemaitre, Jacques
大部分科学界已经接受了一个范例，即模拟身体溶液（SBF）可以用来测试材料的生物活性。使用该测试的出版物数量迅速增加就是例证。本文件的目的是证明：(i)目前没有足够的科学数据来支持这一假设，（ii）即使假设是有效的，测试的一般进行方式仍有改进的余地。提供了支持这些陈述的理论论据和事实，以及所提议的生物活性测试的可能改进。2009爱思唯尔有限公司版权所有。
A large part of the scientific community has accepted the paradigm that a simulated body solution (SBF) can be used to test the bioactivity of a material. This is exemplified by the rapidly increasing number of publications using this test. The aim of this document is to demonstrate that (i) there is presently not enough scientific data to support this assumption, and (ii) even though the assumption was valid, the way the test is generally conducted leaves room for improvement. Theoretical arguments and facts supporting these statements are provided, together with possible improvements of the proposed bioactivity test. (C) 2009 Elsevier Ltd. All rights reserved.