Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: A comparison
Retinal nerve fiber layer birefringence evaluated with polarization sensitive spectral domain OCT and scanning laser polarimetry: A comparison
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DOI：
10.1002/jbio.200710009
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发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Hitzenberger, C. K.
中科院分区：
文献类型：
--
作者：
Goetzinger, E.;Pircher, M.;Hitzenberger, C. K.
采用偏振敏感的光谱域光学相干断层扫描（PS-SD-OCT）系统在体内测量人视网膜神经纤维层（RNFL）的相位延迟和双折射。仪器同时记录三个参数：光强、相位延迟和光轴方向。记录三维数据集，记录健康眼和青光眼视神经头区域的数据集，并以不同的方式呈现结果：根据记录的3D数据生成RNFL的正面相延迟图，并将结果与扫描激光偏振（SLP）进行比较。利用OCT提供的深度信息对强度图像中的RNFL进行分割，并测量RNFL的厚度。根据延迟和厚度数据，导出了RNFL的二维双折射图。将PS-SD-OCT获得的RNFL延迟和厚度的乳头周围图与SLP获得的图像进行定量比较。
A polarization-sensitive spectral domain optical coherence tomography (PS-SD-OCT) system is used to measure phase retardation and birefringence of the human retinal nerve fiber layer (RNFL) in vivo. The instrument records three parameters simultaneously: intensity, phase retardation and optic-axis orientation. 3D data sets are recorded data sets are recorded in the optic nerve head area of a healthy and a glaucomatous eye, and the results are presented in various ways: En-face phase-retardation maps of the RNFL are generated from the recorded 3D data and results are compared with scanning laser polarimetry (SLP). The depth information provided by OCT is used to segment the RNFL in the intensity image and measure the RNFL thickness. From the retardation and thickness data, 2D birefringence maps of the RNFL are derived. Circumpapillary plots of RNFL retardation and thickness obtained by PS-SD-OCT are quantitatively compared with those obtained by SLP.