Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia.
Complement and immunoglobulin studies in 15 cases of chronic meningococcemia: properdin deficiency and hypoimmunoglobulinemia.
复制标题
15 例慢性脑膜炎球菌血症的补体和免疫球蛋白研究：备解素缺乏和低免疫球蛋白血症。
DOI：
10.3109/00365549009023116
复制
发表时间：
1990
影响因子：
--
通讯作者：
Olav J. Bergmann
中科院分区：
文献类型：
--
作者：
Hans Erik Nielsen;Claus Koch;Bendt Mansa;Pascal Magnussen;Olav J. Bergmann
本研究的目的是调查慢性脑膜炎球菌血症患者的体液免疫系统是否存在异常。本文对15例慢性脑膜炎双球菌血症恢复者的补体系统、伊加、IgG、IgM及IgG亚类进行了研究。我们发现一个人完全缺乏备解素，补体旁路途径的一个组成部分。在其他患者中，补体系统正常。患者组的平均血浆IgG浓度显著低于正常值，而伊加、IgM和IgG亚类的平均值均正常。然而，有两个人的IgG 2和IgG 4水平较低。我们的结论是备解素缺乏和血浆IgG水平降低可能易患慢性脑膜炎球菌病，但大多数慢性脑膜炎球菌血症患者的体液免疫系统正常。
The purpose of this study was to investigate whether patients with chronic meningococcemia have abnormalities in their humoral immune system. The alternative and classical complement system, the levels of IgA, IgG and IgM, as well as IgG subclasses were studied in 15 individuals who had recovered from chronic meningococcemia. We found one individual with complete deficiency of properdin, a component of the alternative complement pathway. In the other patients, the complement system was normal. The mean plasma IgG concentration was significantly below normal in the patient group, while the mean values of IgA, IgM and the IgG subclasses were normal. Two individuals, however, had low IgG2 and IgG4 levels. We conclude that properdin deficiency and reduced plasma IgG levels may predispose to chronic meningococcal disease, but that the majority of patients with chronic meningococcemia have a normal humoral immune system.