DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression
DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression
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DYNC1I1通过上调IL-6表达促进胃癌增殖和迁移
DOI：
10.3389/fonc.2019.00491
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发表时间：
2019-06-12
影响因子：
4.7
通讯作者：
Qu, Xiu-Juan
中科院分区：
文献类型：
--
作者：
Gong, Li-Bao;Wen, Ti;Qu, Xiu-Juan
胃癌是世界五大恶性肿瘤之一。目前，胃癌发生发展的分子机制尚不完全清楚。细胞质动力蛋白调节细胞内转运和有丝分裂纺锤体定位，其异常功能在肿瘤发生、促进肿瘤细胞周期进展和肿瘤迁移中至关重要。DYNC 1 I1是细胞质动力蛋白的重要结合亚基。然而，DYNC 1 I1在肿瘤中的研究目前有限。在目前的研究中，我们发现DYNC 1 I1在胃癌中的高表达与不良预后相关，并且是一个独立的预后因素。DYNC 1 I1在体内外均能促进胃癌细胞的增殖和迁移。DYNC 1 I1还通过增加NF-κB核转位上调IL-6表达。总的来说，这些数据揭示了DYNC 1 I1驱动的IL-6/STAT通路在胃癌增殖和迁移中的重要作用，表明DYNC 1 I1可能是胃癌的潜在治疗靶点。
Gastric cancer is one of the top five malignant tumors worldwide. At present, the molecular mechanisms of gastric cancer progression are still not completely clear. Cytoplasmic dynein regulates intracellular transport and mitotic spindle localization, and its abnormal function is crucial for tumorigenesis, promotes tumor cell cycle progression, and tumor migration. DYNC1I1 is an important binding subunit of cytoplasmic dynein. However, studies on DYNC1I1 in tumors are currently limited. In the current study, we found that high DYNC1I1 expression in gastric cancer is associated with poor prognosis and is an independent prognostic factor. DYNC1I1 promoted the proliferation and migration of gastric cancer cells both in vitro and in vivo. DYNC1I1 also upregulated IL-6 expression by increasing NF-κB nuclear translocation. Collectively, these data revealed an important role for the DYNC1I1-driven IL-6/STAT pathway in gastric cancer proliferation and migration, suggesting that DYNC1I1 may be a potential therapeutic target for gastric cancer.