The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat
The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat
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DOI：
10.1016/s0006-8993(01)03208-5
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发表时间：
2001-12-27
期刊：
影响因子：
2.9
通讯作者：
Civelli, O
中科院分区：
文献类型：
--
作者：
Clark, SD;Nothacker, HP;Civelli, O
尾加压素II(UII)是一种已知是一种有效的血管收缩因子的多肽。尾加压素II受体(UII-R)不仅在啮齿类动物的外周组织中表达，在脑中也有表达。作为研究UII中枢神经系统作用的基础，用原位杂交和原位结合的方法分析了UII-R在大鼠脑内的定位。与胆碱乙酰转移酶共存的UII-R m RNA主要分布于桥脑中盖区。结合部位分布于全脑，在桥小脑脚被盖区、背外侧被盖区、外侧隔核、缰核内侧核和脚间核中含量最高。这些脑核中的大多数是起源于桥中脑区的轴突终末部位，提示UII-R是突触前受体。这种UII-R的分布。在胆碱能脑桥脑区，提示UII系统可能参与感觉-运动整合，并可能参与中枢神经系统的血流。(C)2001 Elsevier Science B.V.保留所有权利。
Urotensin II (UII) is a peptide known to be a potent vasoconstrictor. The urotensin II receptor (UII-R) is expressed not only in peripheral tissues but also in the brain of rodents. As a basis for studies of UII central nervous system actions, UII-R localization in the rat brain was analyzed by in situ hybridization and by in situ binding. UII-R mRNA was found in the mesopontine tegmental area colocalizing with choline acetyltransferase. Binding sites were detected throughout the brain with the highest levels found in the pedunculopontine tegmental area, the lateral dorsal tegmental area, and the lateral septal, medial habenular, and interpeduncular nuclei. The majority of these brain nuclei are sites of axonal termination originating from the mesopontine areas, suggesting that UII-R is a presynaptic receptor. This distribution of UII-R. in the cholinergic mesopontine area indicates that the UII system may be involved in sensory-motor integration and perhaps in central nervous system blood flow. (C) 2001 Elsevier Science B.V. All rights reserved.