An FPGA-Based Open Platform for Ultrasound Biomicroscopy
An FPGA-Based Open Platform for Ultrasound Biomicroscopy
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DOI：
10.1109/tuffc.2012.2344
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发表时间：
2012-07-01
影响因子：
3.6
通讯作者：
Sun, Lei
中科院分区：
文献类型：
--
作者：
Qiu, Weibao;Yu, Yanyan;Sun, Lei
超声生物显微镜（UBM）已广泛应用于小动物模型的临床前研究。个体动物研究是独特的，需要不同的UBM系统的使用，以适应不同的传感器特性，数据采集策略，信号处理和图像重建方法。有一个灵活和开放的UBM平台的需求，允许用户定制系统的各种研究，并有充分的实验数据访问。本文介绍了一个开放的UBM平台（中心频率20至80 MHz）的各种临床前研究的发展。该平台设计基于嵌入在印刷电路板中的现场可编程门阵列（FPGA），实现B模式成像和定向脉冲波多普勒。该平台的滤波、包络检波、扫描转换等功能均由FPGA程序实现，无需硬件电路，因此系统结构可以根据具体应用进行修改。此外，还实现了一种新的数字正交解调算法，以实现快速准确的多普勒轮廓。最后，测试结果表明，该平台可以提供25 μ V的最小可检测信号，允许在47 dB增益下的51 dB动态范围，以及超过500帧/秒的实时成像。进行了体模和活体成像实验，结果表明系统性能良好。
Ultrasound biomicroscopy (UBM) has been extensively applied to preclinical studies in small animal models. Individual animal study is unique and requires different utilization of the UBM system to accommodate different transducer characteristics, data acquisition strategies, signal processing, and image reconstruction methods. There is a demand for a flexible and open UBM platform to allow users to customize the system for various studies and have full access to experimental data. This paper presents the development of an open UBM platform (center frequency 20 to 80 MHz) for various preclinical studies. The platform design was based on a field-programmable gate array (FPGA) embedded in a printed circuit board to achieve B-mode imaging and directional pulsed-wave Doppler. Instead of hardware circuitry, most functions of the platform, such as filtering, envelope detection, and scan conversion, were achieved by FPGA programs; thus, the system architecture could be easily modified for specific applications. In addition, a novel digital quadrature demodulation algorithm was implemented for fast and accurate Doppler profiling. Finally, test results showed that the platform could offer a minimum detectable signal of 25 mu V, allowing a 51 dB dynamic range at 47 dB gain, and real-time imaging at more than 500 frames/s. Phantom and in vivo imaging experiments were conducted and the results demonstrated good system performance.