Antibiotic resistance among fecal indicator bacteria from healthy individually owned and kennel dogs
Antibiotic resistance among fecal indicator bacteria from healthy individually owned and kennel dogs
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DOI：
10.1089/107662904323047826
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发表时间：
2004-03-01
影响因子：
2.6
通讯作者：
Haesebrouck, F
中科院分区：
文献类型：
--
作者：
De Graef, EM;Decostere, A;Haesebrouck, F
对从临床健康犬的肛拭子中分离的大肠埃希菌和粪肠球菌进行了获得性耐药检测。这些毒株来自92个不同主人的狗和8个繁育犬舍。本研究的目的是评估狗肠道菌群的耐药性情况，以评估狗菌群作为抗菌素耐药性储存库的可能作用。从个体拥有的狗身上收集的大肠杆菌菌株中很少发现多重耐药性，而从犬舍中收集的菌株则相反。私营犬的大肠杆菌对氨苄西林、甲氧嘧啶和磺胺甲恶唑的耐药性明显低于养犬的菌株。粪肠球菌对四环素和大环内酯类药物的耐药率出人意料地高。分别来自个体所有的狗和养狗犬的两株和三株粪肠球菌对庆大霉素产生了抗药性，庆大霉素是一种经常用于治疗人类肠球菌感染的抗生素。这项研究表明，抗性百分比可能会随着犬只数量的选择而波动。观察到的抗菌素耐药率表明，健康犬的菌群可能是耐药基因的储存库。
Escherichia coli and Enterococcus faecalis strains isolated from anal swabs of clinically healthy dogs were examined for the presence of acquired antimicrobial resistance. The strains originated from dogs of 92 different owners and from eight breeding kennels. The purpose of the present study was to evaluate the resistance situation in the intestinal flora of the dog to assess the possible role of the dog flora as a reservoir of antimicrobial resistance. Multiple resistance was rarely found in E. coli strains collected from individually owned dogs, in contrast with strains from kennel dogs. Resistance to ampicillin, trimethoprim, and sulfamethoxazole was significantly less prevalent in E. coli from privately owned dogs than in strains from kennel dogs. Resistance rates against tetracycline and macrolides were unexpectedly high in E. faecalis strains. Two and three E. faecalis strains from individually owned dogs and kennel dogs, respectively, were resistant to gentamicin, an antibiotic often used for treating enterococcal infections in humans. This study demonstrates that resistance percentages may fluctuate with the choice of dog population. The observed antimicrobial resistance percentages indicate that the flora of healthy dogs may act as a reservoir of resistance genes.