Glucose estimation in the salivary secretion of diabetes mellitus patients.
Glucose estimation in the salivary secretion of diabetes mellitus patients.
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DOI：
10.2147/dmso.s32112
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Oza N
中科院分区：
文献类型：
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作者：
Abikshyeet P;Ramesh V;Oza N
唾液是人体中最丰富的分泌物之一，其采集容易且无创。本研究的目的是找到一种可用于诊断和监测糖尿病的介质。在这方面，唾液可能会发挥重要作用。为了证实唾液作为一种诊断工具的作用，我们在健康受试者和糖尿病患者中对唾液样本与血糖和糖化血红蛋白（HbA1c）进行了比较。
研究纳入了106例新诊断为2型糖尿病的患者和15例健康对照受试者。要求患者和对照受试者在禁食8小时后的早晨来到诊所。当时，采集了5毫升静脉血，其中2毫升采集到含有乙二胺四乙酸（EDTA）的采血管中，并送去进行HbA1c测定。同时也从两组中采集了非刺激性唾液。对血液样本中的唾液和血清进行了血糖测定。
计算了对照组中血清葡萄糖和唾液葡萄糖之间的相关系数，r值为0.5216，具有统计学意义（P < 0.05）。还计算了患者组中血清葡萄糖和唾液葡萄糖之间的相关系数，r值为0.7686，具有高度显著性（P < 0.01）。最后，计算了患者组中HbA1c水平和唾液葡萄糖之间的相关系数，r值为0.5662，也具有高度显著性（P < 0.01）。
Saliva is one of the most abundant secretions in the human body and its collection is easy and noninvasive. The aim of this study was to find a medium that can be used to diagnose and monitor diabetes. In this, saliva could play a major role. To substantiate the role of saliva as a diagnostic tool, we compared saliva samples with blood glucose and glycated hemoglobin (HbA1c) in healthy and diabetic subjects. Included in the study were 106 patients, newly diagnosed with type 2 diabetes mellitus and 15 healthy control subjects. The patients and control subjects were asked to come to the clinic in the morning, after an 8-hour fast. At that time, 5 mL of venous blood was collected, 2 mL of which was collected in an ethylenediaminetetraacetic acid (EDTA)-containing blood collection tube and sent for HbA1c estimation. Unstimulated saliva was collected from both groups as well. The saliva and sera from the blood samples were subjected to glucose estimation. The correlation coefficient between serum glucose and salivary glucose in the control group was calculated and the r value was found to be 0.5216, which was statistically significant (P < 0.05). The correlation coefficient between serum glucose and salivary glucose in the patient group was also calculated and the r value was found to be 0.7686, which was highly significant (P < 0.01). Finally, the correlation coefficient between HbA1c level and salivary glucose in the patient group was calculated and the r value was found to be 0.5662, which was also highly significant (P < 0.01).