High Dietary Acid Load Score Is Associated with Increased Risk of Type 2 Diabetes in Japanese Men: The Japan Public Health Center-based Prospective Study
High Dietary Acid Load Score Is Associated with Increased Risk of Type 2 Diabetes in Japanese Men: The Japan Public Health Center-based Prospective Study
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DOI：
10.3945/jn.115.225177
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发表时间：
2016-05-01
影响因子：
4.2
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
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作者：
Akter, Shamima;Kurotani, Kayo;Tsugane, Shoichiro
背景：饮食引起的代谢性酸中毒与西方人的心脏代谢异常有关，但在亚洲这方面的证据很少。目的：本研究前瞻性地研究了日本成年人膳食酸负荷与2型糖尿病（T2D）之间的关系。方法：研究参与者为27,809名男性和36,851名女性，年龄在45-75岁之间，他们完成了日本公共卫生中心前瞻性研究第二次调查的饮食问卷，之前没有T2D病史。通过使用一份包含147个条目的食物频率问卷来评估膳食摄入量。潜在肾酸负荷（PRAL）和净内源性产酸（NEAP）评分由营养摄入量得出。采用多水平logistic回归模型估计5年内自我报告、医生诊断的T2D的or和95% ci，并对潜在的混杂变量进行调整。结果：共报告新诊断t2dm 1191例。PRAL评分与男性T2D呈正相关；PRAL最低至最高四分位数的多变量调整ORs （95% ci）分别为1.00、1.09（0.87、1.36）、1.10（0.88、1.37）、1.25(1.01、1.55)（P-trend = 0.047）。进一步调整饮食摄入加强了这种联系。NEAP评分与T2D风险无相关性（P-trend = 0.20）。在分层分析中，PRAL和T2D之间的正相关仅局限于年龄较小的男性
Background: Diet-induced metabolic acidosis has been linked to cardiometabolic abnormalities in Westerners, but the evidence on this issue is scarce in Asians.Objective: The present study prospectively examined the association between dietary acid load and type 2 diabetes (T2D) in Japanese adults.Methods: Study participants were 27,809 men and 36,851 women, aged 45-75 y, who completed a dietary questionnaire of the second survey of the Japan Public Health Center based Prospective Study and had no previous history of T2D. Dietary intake was assessed by using a validated 147-item food-frequency questionnaire. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores were derived from the nutrient intake. A multilevel logistic regression model was used to estimate ORs and 95% Cis of self-reported, physician-diagnosed T2D over 5 y, with adjustment for potential confounding variables.Results: A total of 1191 cases of newly diagnosed T2D were reported. PRAL score was positively associated with T2D in men; the multivariable-adjusted ORs (95% CIs) for the lowest through the highest quartiles of PRAL were 1.00, 1.09 (0.87, 1.36), 1.10 (0.88, 1.37), and 1.25 (1.01, 1.55) (P-trend = 0.047). Further adjustment for dietary intake strengthened the association. NEAP score was not associated with the risk of T2D (P-trend = 0.20). In stratified analyses, the positive association between PRAL and T2D was confined to younger men (age