Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging
Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging
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DOI：
10.1117/1.3589097
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发表时间：
2011-06-01
影响因子：
3.5
通讯作者：
Chen, Zhongping
中科院分区：
文献类型：
--
作者：
Yin, Jiechen;Li, Xiang;Chen, Zhongping
我们开发了一种小型集成光学相干断层扫描(OCT)超声(US)探测系统，用于血管内成像应用。在OCT探头中，来自单模光纤的光通过梯度折射率透镜聚焦，然后通过直角棱镜从探头一侧反射到样品中。并与35 MHz PMN-PT侧视超声换能器相结合，获得超声图像。将OCT和超声探头集成为单一探头，同时获得OCT和超声图像。该集成探测器的外径为0.69毫米，据我们所知，这是OCT-US报道的最小的集成探测器。实现了实时成像的快速数据采集和处理。利用集成的OCT-US探头获得了体外病理冠状动脉的OCT和US图像，以及正常兔腹主动脉的在体图像，以验证其性能。(C)2011年，光学仪器工程师学会。[DOI：10.1117/1.3589097]
We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3589097]