Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia.
Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia.
复制标题
多巴胺D2受体基因-141C插入/缺失多态性对精神分裂症患者纹状体多巴胺系统的影响
DOI：
10.1016/j.psychres.2018.03.029
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yabe H
中科院分区：
文献类型：
--
作者：
Matsumoto J;Nagaoka A;Kunii Y;Miura I;Hino M;Niwa SI;Nawa H;Takahashi H;Kakita A;Yabe H
多巴胺D2受体基因- 141C插入/缺失（Ins/Del）多态性与两种多巴胺系统集成体，即多巴胺和camp调节的分子量为32 kDa的磷酸化蛋白（DARPP-32）和钙调神经磷酸酶（CaN）之间的关系尚不清楚。在这项研究中，我们评估了这种多态性对精神分裂症患者和对照个体死后纹状体中DARPP-32和CaN蛋白表达的影响。截断的DARPP和CaN在Del等位基因携带者中表达水平较低。这些发现为这种基因型可能导致抗精神病药物反应不良的机制提供了重要的见解。
The relationships between −141C insertion/deletion (Ins/Del) polymorphisms in the dopamine D2 receptor gene and the two dopamine system integrators, i.e., dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) and calcineurin (CaN), are still unclear. In this study, we assessed the effect of this polymorphism on DARPP-32 and CaN protein expression in the postmortem striatum of patients with schizophrenia and control individuals. The expression levels of truncated DARPP and CaN were lower in Del allele carriers. These findings provide important insights into the mechanism by which this genotype could result in a poor response to antipsychotic drugs.