Variation in the Shape of Pulsed Arterial Spin Labeling Kinetic Curves across the Healthy Human Brain and Its Implications for CBF Quantification
Variation in the Shape of Pulsed Arterial Spin Labeling Kinetic Curves across the Healthy Human Brain and Its Implications for CBF Quantification
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DOI：
10.1002/mrm.21886
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
Gallichan, Daniel;Jezzard, Peter
动脉自旋标记（ASL）使用近端反转的血液水自旋作为内源性造影剂来测量组织中的血液灌注。在这项工作中，脉冲ASL被用来测量脑血流（CBF）的动力学曲线在八个解剖学为基础的兴趣区（ROI）在五个正常健康受试者。当使用单个反转时间与将动力学模型拟合到所有10个测量的反转时间时，比较基于这些数据的CBF估计值。当使用标准双参数方法（CBF和推注到达时间）或最近提出的三参数模型（CBF、推注到达时间和到达时间离散度）拟合10个反转时间数据时，还比较了CBF估计值。动力学曲线形状的变化在整个大脑中被发现，在不同的受试者中是一致的。当使用1.5 s的单个反转时间时，发现枕叶ROI中的到达时间足够长，导致低估CBF。在八个ROI中的四个中，与三参数方法相比，使用标准的双参数模型对CBF有显著的低估。这些结果具有重要意义的发展，一个强大的，定量ASL协议。Magn Reson Med 61：686-695，2009. (C)2009 Wiley-Liss，Inc.
Arterial spin labeling (ASL) uses proximally inverted blood water spins as an endogenous contrast agent to measure blood perfusion in tissue. In this work pulsed ASL was used to measure the kinetic curves of cerebral blood flow (CBF) across eight anatomically based regions of interest (ROIs) in five normal healthy subjects. CBF estimates based on these data were compared when obtained using a single inversion time versus fitting a kinetic model to all 10 measured inversion times. CBF estimates were also compared when fitting to the 10 inversion time data using a standard two-parameter approach (CBF and bolus arrival time) or a more recently proposed three-parameter model (CBF, bolus arrival time, and arrival time dispersion). Variations in the shape of the kinetic curve were found across the brain that were consistent across subjects. The arrival time in the occipital ROI was found to be long enough to lead to underestimation of the CBF when using a single inversion time of 1.5 s. In four out of the eight ROIs there was significant underestimation of CBF using the standard two-parameter model compared to the three-parameter approach. These results have important implications for the development of a robust, quantitative ASL protocol. Magn Reson Med 61: 686-695, 2009. (C) 2009 Wiley-Liss, Inc.