Education and occupations preceding Parkinson disease - A population-based case-control study
Education and occupations preceding Parkinson disease - A population-based case-control study
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DOI：
10.1212/01.wnl.0000184520.21744.a2
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发表时间：
2005-11-22
期刊：
影响因子：
9.9
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Frigerio, R;Elbaz, A;Rocca, WA
目的：采用病例对照研究设计，探讨帕金森病（PD）与教育和职业的关系。方法：作者使用罗切斯特流行病学项目的病历-联系系统，确定1976年至1995年明尼苏达州奥姆斯特德县发生PD的所有受试者。每个事件病例的年龄（+/- 1岁）和性别与一般人群对照相匹配。作者使用两个独立的数据来源收集了有关教育和职业的信息：对系统中完整医疗记录的回顾和电话采访。职业编码使用1980年标准职业Classification.Results：受教育9年或以上的PD的风险增加（OR = 2.0; 95%CI = 1.1至3.6; P = 0.02），并有一个趋势，随着教育程度的增加，风险增加（线性趋势检验，P = 0.02;医疗记录数据）。使用这两种职业数据来源，医生患PD的风险显著增加。相比之下，使用一个数据来源，四个职业组显示出PD的风险显著降低：建筑和采掘工人（e.例如，在一个实施例中，矿工、油井钻探工）、生产工人（e.例如，在一个实施例中，机器操作员、制造商）、金属工人和工程师。这些协会与增加或减少的风险没有明显改变调整后的教育。结论：具有高等教育和医生的主题有帕金森病（PD）的风险增加，而与一些职业假定涉及高体力活动的主题有PD的风险降低。
Objective: To investigate the association of Parkinson disease ( PD) with education and occupations using a case- control study design.Methods: The authors used the medical records- linkage system of the Rochester Epidemiology Project to identify all subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age ( +/- 1 year) and sex to a general population control. The authors collected information about education and occupations using two independent sources of data: a review of the complete medical records in the system and a telephone interview. Occupations were coded using the 1980 Standard Occupational Classification.Results: Subjects with 9 or more years of education were at increased risk of PD ( OR = 2.0; 95% CI = 1.1 to 3.6; p = 0.02), and there was a trend of increasing risk with increasing education ( test for linear trend, p = 0.02; medical records data). Physicians were at significantly increased risk of PD using both sources of occupational data. By contrast, four occupational groups showed a significantly decreased risk of PD using one source of data: construction and extractive workers ( e. g., miners, oil well drillers), production workers ( e. g., machine operators, fabricators), metal workers, and engineers. These associations with increased or decreased risk did not change noticeably after adjustment for education.Conclusion: Subjects with higher education and physicians have an increased risk of Parkinson disease ( PD), while subjects with some occupations presumed to involve high physical activity have a decreased risk of PD.