C-reactive protein and the biology of disease
C-reactive protein and the biology of disease
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DOI：
10.1007/s12026-013-8384-0
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发表时间：
2013-05-01
影响因子：
4.4
通讯作者：
Ghosh, Shyamasree
中科院分区：
文献类型：
--
作者：
Ansar, Waliza;Ghosh, Shyamasree
c反应蛋白（CRP）是一种起源于肝脏的血浆蛋白，属于戊烷素家族，是任何炎症反应的主要组成部分。作为先天免疫途径的关键组成部分，由于组织损伤或感染，CRP的浓度可能迅速增加到高于正常值1000倍以上的水平。虽然它是先天免疫的经典介质，但它通过炎症的体液和细胞效应系统的相互作用发挥作用。它最初被认为是组织损伤、感染和炎症的急性期标志物，现在在心血管疾病中具有明确的疾病标志物地位，其临床和病理意义是众所周知的。目前对大量疾病和相关病症的大量研究已经高度阐明了CRP作为治疗和研究试剂的作用。在这篇综述中，我们关注CRP在健康和疾病中的作用。这篇综述的未来前景在于CRP作为一种分子在理解和监测疾病生物学方面的适用性。
The C-reactive protein (CRP) is a plasma protein of hepatic origin, belonging to pentraxin family and forms a major component of any inflammatory reaction. A key component of the innate immunity pathway, the concentration of CRP may rapidly increase to levels more than 1,000-folds above normal values as a consequence to tissue injury or infection. Although functioning as a classical mediator of innate immunity, it functions via interaction of components of both humoral and cellular effector systems of inflammation. Initially considered as an acute-phase marker in tissue injury, infection and inflammation, it now has a distinct status of a disease marker in cardiovascular diseases and is well known of its clinical and pathological significance. The present torrent of studies in a large number of diseases and associated conditions has highly elucidated the role of CRP as a therapeutic and research reagent. In this review, we focus our attention to role of CRP in health and disease. The future prospect of this review lies in the applicability of CRP as a molecule in understanding and monitoring of the biology of disease.