Artificial gravity with ergometric exercise preserves the cardiac, but not cerebrovascular, functions during 4 days of head-down bed rest.
Artificial gravity with ergometric exercise preserves the cardiac, but not cerebrovascular, functions during 4 days of head-down bed rest.
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DOI：
10.1016/j.cyto.2011.09.004
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发表时间：
2011-12
期刊：
影响因子：
3.8
通讯作者：
Chang-bin Yang;Yong-chun Wang;Yuan Gao;J. Geng;Yan-hong Wu;Yu Zhang;F. Shi;Xi-qing Sun
中科院分区：
文献类型：
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作者：
Chang-bin Yang;Yong-chun Wang;Yuan Gao;J. Geng;Yan-hong Wu;Yu Zhang;F. Shi;Xi-qing Sun
在长期航天飞行中发生的心血管和肌肉骨骼失调需要新的战略来抵消这些不利影响。我们曾报道，短臂离心机产生的人工重力（AG）与测力计配合使用，对心血管功能有一定的促进作用。本研究旨在探讨头低位卧床（HDBR）4 d后，AG结合运动训练对心血管功能的影响是否能维持和改善心脑血管功能。12名健康男性受试者被分为对照组（CONT，n=6）和AG结合测功运动训练组（CM，n=6）。同时测定心脏泵血功能、心脏收缩功能和脑血流量。结果表明，AG结合测功运动后，耐力值有增加趋势，但两组间无显著性差异。CONT组在HDBR后4d心率显著增加（59± 6vs 66± 7次/min），每搏输出量（98±12 vs 68± 13 mL）和心输出量（6± 1vs 4± 1 L/min）显著减少（p<0.05）。所有受试者的脑血管功能下降相似。两组血容量调节激素醛固酮均增加（CONT组增加119.9%，CM组增加112.8%），但仅CONT组变化显著（p<0.05）。HDBR 4天后，CONT组血管紧张素II显著增加140.5%（p<0.05），而CM组无显著变化。这些结果表明，人工重力加测功运动成功地消除了模拟失重引起的心率、容量调节激素和心脏泵血功能的变化，并部分维持了心脏收缩功能。因此，每天1h交替+1.0和+2.0Gz +40W运动训练似乎是对抗心脏失调的有效对策。
Cardiovascular and musculoskeletal deconditioning occurring in long-term spaceflight requires new strategies to counteract these adverse effects. We previously reported that a short-arm centrifuge produced artificial gravity (AG), together with ergometer, has an approving effect on promoting cardiovascular function. The current study sought to investigate whether the cardiac and cerebrovascular functions were maintained and improved using a strategy of AG combined with exercise training on cardiovascular function during 4-day head-down bed rest (HDBR). Twelve healthy male subjects were assigned to a control group (CONT, n=6) and an AG combined with ergometric exercise training group (CM, n=6). Simultaneously, cardiac pumping and systolic functions, cerebral blood flow were measured before, during, and after HDBR. The results showed that AG combined with ergometric exercise caused an increase trend of number of tolerance, however, there was no significant difference between the two groups. After 4-day HDBR in the CONT group, heart rate increased significantly (59±6 vs 66±7beats/min), while stroke volume (98±12 vs 68±13mL) and cardiac output (6±1 vs 4±1L/min) decreased significantly (p<0.05). All subjects had similar drops on cerebral vascular function. Volume regulating hormone aldosterone increased in both groups (by 119.9% in CONT group and 112.8% in the CM group), but only in the CONT group there were a significant changes (p<0.05). Angiotensin II was significantly increased by 140.5% after 4-day HDBR in the CONT group (p<0.05), while no significant changes were observed in the CM group. These results indicated that artificial gravity with ergometric exercise successfully eliminated changes induced by simulated weightlessness in heart rate, volume regulating hormones, and cardiac pumping function and partially maintained cardiac systolic function. Hence, a daily 1h alternating +1.0 and +2.0Gz with 40W exercise training appear to be an effective countermeasure against cardiac deconditioning.