Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice
Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice
复制标题
DOI：
10.1016/j.jtemb.2007.08.003
复制
发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Sugiyama, Toshihiro
中科院分区：
文献类型：
--
作者：
Kawagoe, Masami;Ishikawa, Kiyoshi;Sugiyama, Toshihiro
我们评估了通过成年小鼠灌胃、通过乳汁给新生小鼠和经胎盘给药给药引起的组织变化。成人的改变包括广泛的肺出血、肺静脉充血、肺泡间隔增厚、肝坏死和中性粒细胞渗出。胎鼠则表现为肺、肝淤血。这些结果表明，尽管口服毒性相当低，但灌胃给药可引起微小的组织变化。这些变化在新生小鼠和胎鼠中没有那么严重。成年小鼠尾静脉注射Ce后，Ce主要分布于肝、脾、肺，呈剂量依赖性，3d后浓度逐渐降低。Ce对小鼠血浆的抗凝作用研究表明，当Ce加入到血浆中时，凝血时间明显延长。这些结果提示，Ce可干扰凝血，引起肺、肝血管充血。(C)2007年爱思唯尔股份有限公司。版权所有。
We evaluated tissue changes associated with cerium chloride administration via gavage to adult mice, via milk to neonatal mice and transplacentally to fetal mice. Change in adults consisted of extensive pulmonary hemorrhage, pulmonary venous congestion, thickened alveolar septae, hepatic necrosis and neutrophil infiltrations. Those in fetal mice consisted of pulmonary and hepatic congestion. These results indicate that gavage cerium administration elicited subtle tissue changes, though oral toxicity is rather low. These changes were less severe in neonatal and fetal mice. When cerium was injected into adult mice through the tail vein, cerium was distributed mainly to the liver, spleen and lung dose-dependently with the cerium concentration gradually decreasing after 3 days. A study of cerium anticoagulation in mouse plasma showed that clotting time was significantly prolonged when cerium was added to plasma. These results suggest that cerium may disturb blood coagulation and cause pulmonary and hepatic vascular congestion. (C) 2007 Elsevier GmbH. All rights reserved.