Rho-kinase: regulation, (dys)function, and inhibition.
Rho-kinase: regulation, (dys)function, and inhibition.
复制标题
Rho 激酶：调节、功能（功能障碍）和抑制。
DOI：
10.1515/hsz-2013-0181
复制
发表时间：
2013-11
影响因子：
3.7
通讯作者：
Ahmadian MR
中科院分区：
文献类型：
--
作者：
Amin E;Dubey BN;Zhang SC;Gremer L;Dvorsky R;Moll JM;Taha MS;Nagel-Steger L;Piekorz RP;Somlyo AV;Ahmadian MR
在各种正常和病理细胞类型中，Rho-kinase I和II(ROKI/II)在非肌肉和平滑肌细胞骨架和黏附斑块的组织以及转录因子的调控中发挥着关键作用。因此，Rocki/II活性调节细胞的收缩、运动、形态、极性、细胞分裂和基因表达。新的证据表明，Rho-Rock通路在不同阶段的失调与心血管、代谢和神经退行性疾病以及癌症有关。本文就Rho-ROCK信号通路的多种功能以及Rho-ROCK活动的各种调控模式，从而协调一致的功能反应的研究现状作一综述。
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.