FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides.
FoxP3-positive T cell lymphoma arising in non-HTLV1 carrier: clinicopathological analysis of 11 cases of PTCL-NOS and 2 cases of mycosis fungoides.
复制标题
非HTLV1携带者FoxP3阳性T细胞淋巴瘤：11例PTCL-NOS和2例蕈样肉芽肿的临床病理分析
DOI：
10.1111/his.12885
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发表时间：
2016
期刊：
影响因子：
6.4
通讯作者：
Nakamura S.
中科院分区：
文献类型：
--
作者：
Satou A;Asano N;Kato S;Katsuya H;Ishitsuka K;Elsayed AA;Nakamura S.
目的叉头盒蛋白3阳性（FoxP 3+）T细胞淋巴瘤，在没有人类T细胞嗜淋巴病毒1型（HTLV-1）感染的情况下，是罕见的，其临床病理特征仍不清楚。本研究的目的是阐明其characteristic.Methods和resultsWe在这里描述11例外周T细胞淋巴瘤未另行说明（PTCL-NOS）和两例真菌病fingoides（MF）FoxP 3阳性。11例PTCL-NOS病例的中位年龄为65岁（范围：48-80岁），所有患者均为男性。根据国际预后指数，8例患者（80%）显示III/IV期疾病，6例（60%）被归类为高-中/高风险组。2例MF病例为57岁和59岁男性。根据国际皮肤淋巴瘤协会/欧洲癌症研究和治疗组织（ISCL/EORTC）分类，这两例病例均被归类为IA期。免疫组化结果显示，所有病例细胞毒分子标志物均为阴性，9例（75%）为αβ T细胞型。结论FoxP 3 + PTCL-NOS是一种预后不良的小亚型，部分患者存在EB病毒再激活。相反，两例MF表现出无痛的临床过程，这是从以前报告的皮肤T细胞淋巴瘤（CTCL）的情况下不同。
AimsForkhead box protein 3‐positive (FoxP3+) T cell lymphoma, in the absence of human T cell lymphotrophic virus type 1 (HTLV‐1) infection, is rare and its clinicopathological characteristics still remain unclear. The aim of this study was to elucidate its characteristics.Methods and resultsWe describe here 11 cases of peripheral T cell lymphoma not otherwise specified (PTCL‐NOS) and two cases of mycosis fingoides (MF) which were positive for FoxP3. The median age of the 11 PTCL‐NOS cases was 65 years (range: 48–80 years), and all the patients were male. Eight patients (80%) showed stages III/IV disease, and six (60%) were categorized as high–intermediate/high‐risk groups according to the International Prognostic Index. Two cases of MF were 57‐ and 59‐year‐old males. Both cases were categorized as stage IA, according to International Society for Cutaneous Lymphomas/European Organization of Research and Treatment of Cancer (ISCL/EORTC) classification. Immunohistochemically, all the cases were negative for cytotoxic molecule marker, and nine (75%) were αβ T cell type. Scattered Epstein–Barr virus (EBV)‐infected cells were detected in four cases of PTCL‐NOS, implying the reactivation of EBV caused by the immunodeficient status of the patients.ConclusionsFoxP3+PTCL‐NOS constitute a minor phenotypical subtype with poor prognosis and EBV reactivation in some. Conversely, two cases of MF showed an indolent clinical course which was different from previously reported cutaneous T cell lymphoma (CTCL) cases.