Folic acid reduces nuclear translocation of β-catenin in rectal mucosal crypts of patients with colorectal adenomas
Folic acid reduces nuclear translocation of β-catenin in rectal mucosal crypts of patients with colorectal adenomas
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DOI：
10.1016/j.canlet.2003.10.027
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发表时间：
2004-03-31
期刊：
影响因子：
9.7
通讯作者：
Majumdar, APN
中科院分区：
文献类型：
--
作者：
Jaszewski, R;Millar, B;Majumdar, APN
我们已经证明叶酸可以抑制结肠癌细胞系的细胞增殖和表皮生长因子受体（EGFR）的激活。我们研究了一年补充叶酸（5mg /天）对结直肠腺瘤患者直肠粘膜β -连环蛋白和pgsk3 β表达的影响，已知它们受EGF-R的影响。与安慰剂相比，叶酸处理显著降低了β -catenin的细胞核表达（P < 0.05）和pgsk3 β的细胞表达（P < 0.01）。叶酸可能发挥其化学预防作用，至少部分是通过抑制β -连环蛋白的核易位。(C) 2004年由爱思唯尔爱尔兰有限公司出版
We have demonstrated that folic acid inhibits cell proliferation and epidermal growth factor receptor (EGFR) activation in colon cancer cell lines. We examined the effect of one year supplemental folic acid (5 mg/day) on the rectal mucosal expression of beta-catenin and pGSK3beta, known to be affected by EGF-R, in patients with colorectal adenomas. Folic acid treatment significantly reduced nuclear expression of beta-catenin (P < 0.05) and cellular expression of pGSK3beta (P < 0.01) when compared to placebo. Folic acid may exert its chemopreventive effect, at least in part, through inhibition of nuclear translocation of beta-catenin. (C) 2004 Published by Elsevier Ireland Ltd.