Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease
Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease
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DOI：
10.1016/j.ajpath.2011.05.047
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发表时间：
2011-09-01
影响因子：
6
通讯作者：
Hyman, Bradley T.
中科院分区：
文献类型：
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作者：
Serrano-Pozo, Alberto;Mielke, Matthew L.;Hyman, Bradley T.
老年斑是阿尔茨海默病（AD）的一个突出的病理特征，但对胶质细胞与斑块的关联或整个疾病过程中胶质反应的动力学知之甚少。我们研究了反应性胶质细胞的进展及其与AD病理标志的关系，以测试胶质细胞是否仅与淀粉样蛋白沉积或缠结沉积相关，从而将两种病变整合为疾病严重程度的标志物。我们进行了一项基于定量体视学的尸检研究，对15名非痴呆对照受试者和91名AD患者的颞叶新皮质进行了研究，包括淀粉样蛋白负荷、神经元缠结、反应性星形胶质细胞和活化小胶质细胞的测量。我们还讨论了在邻近的神经胶质反应的进展（
Senile plaques are a prominent pathological feature of Alzheimer's disease (AD)), but little is understood about the association of glial cells with plaques or about the dynamics of glial responses through the disease course. We investigated the progression of reactive glial cells and their relationship with AD pathological hallmarks to test whether glial cells are linked only to amyloid deposits or also to tangle deposition, thus integrating both lesions as a marker of disease severity. We conducted a quantitative stereology-based post-mortem study on the temporal neocortex of 15 control subjects without dementia and 91 patients with AD, including measures of amyloid load, neurofibrillary tangles, reactive astrocytes, and activated microglia. We also addressed the progression of glial responses in the vicinity (