Trends in blood pressure and urinary sodium and potassium excretion in Japan: reinvestigation in the 8th year after the Intersalt Study
Trends in blood pressure and urinary sodium and potassium excretion in Japan: reinvestigation in the 8th year after the Intersalt Study
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DOI：
10.1038/sj.jhh.1000915
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发表时间：
1999-11-01
影响因子：
2.7
通讯作者：
Ueshima, H
中科院分区：
文献类型：
--
作者：
Nakagawa, H;Morikawa, Y;Ueshima, H
使用之前进行的Intersalt研究的相同方案，我们在8年后进行了一项新的研究（Intersalt-2）。我们测量了影响血压（BP）的各种因素的变化，包括尿钠和钾排泄在日本三个地区：大坂，栃木，和富山。此外，我们还评估了这些因素与BP之间关系的趋势。盐间研究显示，所有三个研究中心的平均钠排泄量较高（特别是在富山），而钾排泄量相对较低，因此钠/钾比值相对较高。身体质量指数（BMI）是有利的，但酗酒者的患病率很高。比较第一次和第二次研究显示，富山的钠排泄量减少，尽管该地区仍然是三个研究中心中最高的。平均钾排泄量仅在大坂增加。所有中心的钠/钾比值均降低。两项研究的受试者的BMI和酗酒者的患病率几乎相同。钠与UP的关系在大坂由负向正变化，在富山由正向负变化。人们认为，这种负相关可能与盐的摄入量减少有关。总之，本研究表明，日本的平均钠摄入量仍然很高，而钾的摄入量仍然很低。作为预防高血压的一个因素，仍然需要进一步努力减少盐的消耗和增加钾的摄入。
Using the identical protocol of an Intersalt Study previously conducted, we undertook a new study (Intersalt-2) 8 years later. We measured changes in various factors affecting blood pressure (BP) including urinary sodium and potassium excretion in three districts of Japan: Osaka, Tochigi, and Toyama. Also we evaluated the trends in the relationships of those factors to BP.The Intersalt Study revealed that the average sodium excretion of all three study centres was high (particularly in Toyama) while potassium excretion was relatively low, The sodium/potassium ratio was therefore relatively high. The body mass index (BMI) was favourable, but the prevalence of heavy alcohol drinkers was high.Comparing the first to the second study reveals a decrease in sodium excretion in Toyama, although that area still had the highest value of the three study centres. The average potassium excretion increased only in Osaka. Sodium/potassium ratio decreased in all centres. BMI and the prevalence of heavy drinkers among the subjects of both studies were nearly the same. The trend of the relationship of sodium to UP in Osaka changed from negative to positive, In Toyama, it changed from positive to negative. It is thought that this negative relationship might occur in conjunction with a reduction in salt consumption in a population.In conclusion this study reveals that average sodium consumption in Japan remains high while potassium consumption is still low. As a factor in the prevention of hypertension, further efforts to reduce salt consumption and increase potassium intake are still needed.