CryoETGAN: Cryo-Electron Tomography Image Synthesis via Unpaired Image Translation.
CryoETGAN: Cryo-Electron Tomography Image Synthesis via Unpaired Image Translation.
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DOI:
10.3389/fphys.2022.760404
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发表时间:
2022
影响因子:
4
通讯作者:
Xu M
中科院分区:
文献类型:
--
作者:
Wu X;Li C;Zeng X;Wei H;Deng HW;Zhang J;Xu M
Cryo-electron tomography (Cryo-ET) has been regarded as a revolution in structural biology and can reveal molecular sociology. Its unprecedented quality enables it to visualize cellular organelles and macromolecular complexes at nanometer resolution with native conformations. Motivated by developments in nanotechnology and machine learning, establishing machine learning approaches such as classification, detection and averaging for Cryo-ET image analysis has inspired broad interest. Yet, deep learning-based methods for biomedical imaging typically require large labeled datasets for good results, which can be a great challenge due to the expense of obtaining and labeling training data. To deal with this problem, we propose a generative model to simulate Cryo-ET images efficiently and reliably: CryoETGAN. This cycle-consistent and Wasserstein generative adversarial network (GAN) is able to generate images with an appearance similar to the original experimental data. Quantitative and visual grading results on generated images are provided to show that the results of our proposed method achieve better performance compared to the previous state-of-the-art simulation methods. Moreover, CryoETGAN is stable to train and capable of generating plausibly diverse image samples.
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影响因子:
5.4
作者:
Gupta, Harshit;McCann, Michael T.;Unser, Michael
通讯作者:
Unser, Michael
DOI:
10.1098/rsta.2020.0203
发表时间:
2021-06-28
影响因子:
5
作者:
Lv, Jun;Zhu, Jin;Yang, Guang
通讯作者:
Yang, Guang
影响因子:
3
作者:
Bartesaghi, A.;Sprechmann, P.;Subramaniam, S.
通讯作者:
Subramaniam, S.
影响因子:
64.8
作者:
Basler M;Pilhofer M;Henderson GP;Jensen GJ;Mekalanos JJ
通讯作者:
Mekalanos JJ
DOI:
10.1016/j.compmedimag.2021.101969
发表时间:
2021-09
期刊:
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
影响因子:
--
作者:
Jiang M;Zhi M;Wei L;Yang X;Zhang J;Li Y;Wang P;Huang J;Yang G
通讯作者:
Yang G