Current concepts in biofilm formation of Staphylococcus epidermidis.
Current concepts in biofilm formation of Staphylococcus epidermidis.
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DOI：
10.2217/fmb.10.56
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发表时间：
2010-06
影响因子：
3.1
通讯作者：
Olson ME
中科院分区：
文献类型：
--
作者：
Fey PD;Olson ME
表皮葡萄球菌是一种重要的医院内致病菌，主要介导与留置生物材料(如导管和假体)有关的感染。与金黄色葡萄球菌相比，与表皮葡萄球菌相关的毒力特性很少，生物膜的形成是与疾病相关的决定性毒力因素，生物材料相关感染的动物模型证明了这一点。然而，其他毒力因子，如苯酚可溶性调制素和聚-γ-DL-谷氨酸，最近已被发现阻碍天然免疫系统的机制。表皮葡萄球菌生物被膜的形成通常被认为是一个由附着、积累、成熟和扩散四个步骤组成的过程。本文将讨论这四个步骤的最新研究进展，包括积累，这可以是多糖或蛋白质介导的。据推测，集中于了解葡萄球菌生物被膜形成过程中每一步的生物学功能的研究将产生治疗这些顽固性感染的新的治疗方式。
Staphylococcus epidermidis is a highly significant nosocomial pathogen mediating infections primarily associated with indwelling biomaterials (e.g., catheters and prostheses). In contrast to Staphylococcus aureus, virulence properties associated with S. epidermidis are few and biofilm formation is the defining virulence factor associated with disease, as demonstrated by animal models of biomaterial-related infections. However, other virulence factors, such as phenol-soluble modulins and poly-γ-DL-glutamic acid, have been recently recognized that thwart innate immune system mechanisms. Formation of S. epidermidis biofilm is typically considered a four-step process consisting of adherence, accumulation, maturation and dispersal. This article will discuss recent advances in the study of these four steps, including accumulation, which can be either polysaccharide or protein mediated. It is hypothesized that studies focused on understanding the biological function of each step in staphylococcal biofilm formation will yield new treatment modalities to treat these recalcitrant infections.