Quantifying the impact of gestational diabetes mellitus, maternal weight and race on birthweight via quantile regression.

Quantifying the impact of gestational diabetes mellitus, maternal weight and race on birthweight via quantile regression.
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DOI:
10.1371/journal.pone.0065017
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Hunt KJ
Hunt KJ
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Ellerbe CN;Gebregziabher M;Korte JE;Mauldin J;Hunt KJ

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分位数回归是一种稳健的半参数方法,用于检查妊娠糖尿病 (GDM) 对出生体重分位数的影响,重点关注母亲孕前体重指数 (BMI) 和妊娠体重增加 (GWG)。使用关联的出生证明、住院医院和产前索赔数据,我们检查了 2004 年至 2008 年妊娠 28 至 44 周的南卡罗来纳州非西班牙裔白人(NHW,135,119)和非西班牙裔黑人(NHB,76,675)妇女的活单胎分娩。当母亲 BMI 为 30 kg/m2(出生体重第 90 分位数)时,接触 GDM 与 NHW 中出生体重高出 84 克(95% CI 57, 112)相关,与 NHB 中出生体重高出 132 克(95% CI: 104, 161)相关。第 50 分位数的结果分别为 34 克(95% CI:17、51)和 78 克(95% CI:56、100)。当母亲出生体重第 90 分位数时的 GWG 为 13.5 kg 时,接触 GDM 与 NHW 中出生体重高出 83 克(95% CI:57, 109)相关,NHB 中出生体重高出 135 克(95% CI:103, 167)。第 50 分位数的结果分别为 55 克(95% CI:40、71)和 69 克(95% CI:46、92)。我们的研究结果表明,GDM、母亲孕前 BMI 和 GWG 使 NHW 和 NHB 婴儿的出生体重增加更多,这些婴儿已经处于巨大儿或大于胎龄 (LGA) 的最大风险,即 90 岁的婴儿,而不是出生体重分布中位数的婴儿。
Quantile regression, a robust semi-parametric approach, was used to examine the impact of gestational diabetes mellitus (GDM) across birthweight quantiles with a focus on maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG). Using linked birth certificate, inpatient hospital and prenatal claims data we examined live singleton births to non-Hispanic white (NHW, 135,119) and non-Hispanic black (NHB, 76,675) women in South Carolina who delivered 28–44 weeks gestation in 2004–2008. At a maternal BMI of 30 kg/m2 at the 90th quantile of birthweight, exposure to GDM was associated with birthweights 84 grams (95% CI 57, 112) higher in NHW and 132 grams (95% CI: 104, 161) higher in NHB. Results at the 50th quantile were 34 grams (95% CI: 17, 51) and 78 grams (95% CI: 56, 100), respectively. At a maternal GWG of 13.5 kg at the 90th quantile of birthweight, exposure to GDM was associated with birthweights 83 grams (95% CI: 57, 109) higher in NHW and 135 grams (95% CI: 103, 167) higher in NHB. Results at the 50th quantile were 55 grams (95% CI: 40, 71) and 69 grams (95% CI: 46, 92), respectively. Our findings indicate that GDM, maternal prepregnancy BMI and GWG increase birthweight more in NHW and NHB infants who are already at the greatest risk of macrosomia or being large for gestational age (LGA), that is those at the 90th rather than the median of the birthweight distribution.
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