Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
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DOI：
10.1016/j.bioeng.2006.05.017
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发表时间：
2007-02-01
期刊：
影响因子：
--
通讯作者：
Borros, S.
中科院分区：
文献类型：
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作者：
Garreta, E.;Gasset, D.;Borros, S.
采用等离子体技术对羟基磷灰石粉末进行表面改性。丙烯酸和丙烯酸/辛二烯等离子体沉积在HA颗粒上的薄膜已经证明与SBF相互作用，允许钙的溶解-析出机理。因此，我们开发了一种羟基磷灰石与自组装多肽支架(RAD16-I)之间的纳米复合材料。研究了骨髓间充质干细胞在该支架中的分化情况，以检验新型复合材料的成骨能力。我们观察到，mESC可以在三维微环境中诱导生成钙盐(矿化)，而且这种活性可以通过在纳米纤维支架中加入HA颗粒来增强。(C)2006爱思唯尔B.V.保留所有权利。
A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold. (c) 2006 Elsevier B.V. All rights reserved.