STUDIES UTILIZING MURINE T-CELL CLONES - IR GENES, IA ANTIGENS AND MLR STIMULATING DETERMINANTS
STUDIES UTILIZING MURINE T-CELL CLONES - IR GENES, IA ANTIGENS AND MLR STIMULATING DETERMINANTS
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DOI：
10.1111/j.1600-065x.1981.tb00434.x
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发表时间：
1981-01-01
影响因子：
8.7
通讯作者：
KIMOTO, M
中科院分区：
文献类型：
--
作者：
FATHMAN, CG;KIMOTO, M
大约3年前，在第35卷中，我们提出了关于克隆鼠同种异体反应性T细胞的潜力的初步数据（Watanabe等，1977）。随后，我们可以分离和表征鼠同种异体反应性T细胞的克隆（Fathman & Hengartner 1978，1979a，1979b，Hengartner & Fathman 1980）和与可溶性抗原反应的鼠T细胞的克隆（Kimoto & Fathman 1980）。利用与同种异体抗原反应的克隆，以及与可溶性抗原反应的克隆与针对Ia抗原的单克隆抗体和各种同源、重组同源和突变小鼠的组合，可以证明I区编码的MLR刺激决定簇、Ia抗原和免疫应答基因都与相同的细胞表面产物相关，并且是不可区分的。
Approximately 3 years ago, in Vol. 35, we presented preliminary data regarding the potential for cloning murine alloreactive T cells {Watanabe et al. 1977). Subsequently it has been possible for us to isolate and characterize clones of murine alloreactive T cells {Fathman & Hengartner 1978, 1979a, 1979b, Hengartner & Fathman 1980) and clones of murine T cells reactive with soluble antigens (Kimoto & Fathman 1980). Utilizing clones reactive with alloantigens, as well as clones reactive with soluble antigens in combination with monoclonal antibodies directed at Ia antigens and a variety of congenic, recombinant congenic and mutant mice, it has been possible to demonstrate that I region encoded MLR stimulating determinants, Ia antigens and immune response genes are all associated with the same cell surface products and are indistinguishable.