Asymmetric Direct Vinylogous Conjugate Addition of α,β‐Unsaturated γ‐Butyrolactam to Acyl Acrylonitriles using Organocatalysts
Asymmetric Direct Vinylogous Conjugate Addition of α,β‐Unsaturated γ‐Butyrolactam to Acyl Acrylonitriles using Organocatalysts
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使用有机催化剂将 α,β-不饱和 γ-丁内酰胺不对称直接乙烯共轭加成到酰基丙烯腈上
DOI：
10.1002/ajoc.202300082
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发表时间：
2023
影响因子：
2.7
通讯作者：
Miura Tsuyoshi
中科院分区：
文献类型：
--
作者：
Ishii Daiki;Hirashima Shin‐ichi;Nakashima Kosuke;Matsushima Yasuyuki;Sakai Takaaki;Akutsu Hiroshi;Miura Tsuyoshi
噻吩类有机催化剂有效地促进了α，β-不饱和γ-丁内酰胺与苯甲酰基丙烯腈的不对称直接乙烯基共轭加成反应，得到了具有良好产率和优异立体选择性（高达99%ee）的加成产物。本报告是首次证明α，β-不饱和γ-丁内酰胺与苯甲酰基丙烯腈的不对称直接乙烯基共轭加成的研究。
Thiourea organocatalyst efficiently promotes the asymmetric direct vinylogous conjugate addition of α,β‐unsaturated γ‐butyrolactam to benzoyl acrylonitriles, resulting in corresponding addition products with good yields and excellent stereoselectivities (up to 99% ee). This report is the first study demonstrating the asymmetric direct vinylogous conjugate addition of α,β‐unsaturated γ‐butyrolactam to benzoyl acrylonitriles.