Desymmetrisation of Biphenyl-Based Carbohydrate Receptors: A Nonbonding Pillar in One Corner of the Cage
Desymmetrisation of Biphenyl-Based Carbohydrate Receptors: A Nonbonding Pillar in One Corner of the Cage
复制标题
联苯类碳水化合物受体的去对称化：笼子一角的非键合支柱
作者：
Davis A
We report a new addition to the family of biphenyl-based carbohydrate receptors, derived by replacing one out of four isophthalamide (diamide) linkages with the corresponding diester. The alteration results in lower binding constants, perhaps reflecting the entropic penalty for lowering receptor symmetry. However, the synthesis allows access to many related host molecules, with potential for restoring and raising affinities and tuning selectivities.
