Retinoic acid signaling in myelopoiesis
Retinoic acid signaling in myelopoiesis
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DOI：
10.1097/moh.0b013e3282f20a9c
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Rosmarin, Alan
中科院分区：
文献类型：
--
作者：
Drumea, Karen;Yang, Zhong-fa;Rosmarin, Alan
综述目的几十年来，视黄酸被认为可以改变骨髓细胞的增殖和分化。目前，视黄酸是治疗某些形式的急性髓性白血病的一线药物。在这篇综述中，我们集中在我们的理解维甲酸影响骨髓细胞的生长和增殖的机制，并有助于白血病的发病机制的最新进展。我们没有试图总结相关的临床文献。最近的发现在过去的2年中，已经取得了重要的了解的机制，维甲酸及其核受体与其他信号转导途径和转录因子的相互作用，以修改染色质，改变基因表达，并参与正常的骨髓分化和白血病的发生。有关细胞生物学，分子生物学，生物化学和动物研究的维甲酸和髓系分化的重要进展review.SummaryGreater了解的作用维甲酸及其受体在髓系细胞的生长和分化提供了重要的洞察正常骨髓。这些发现为急性白血病的治疗提供了成功的合理方法，并为在不久的将来改善治疗提供了希望。
Purpose of reviewFor decades, retinoic acid has been known to alter the proliferation and differentiation of myeloid cells. Currently, retinoic acid is a front-line agent in the treatment of certain forms of acute myelogenous leukemia. In this review, we focus on recent advances in our understanding of the mechanisms by which retinoids affect growth and proliferation of myeloid cells and contribute to the pathogenesis of leukemia. We have not attempted to summarize the related clinical literature.Recent findingsThe past 2 years have yielded important understanding of the mechanisms by which retinoids and their nuclear receptors interact with other signal transduction pathways and transcription factors to modify chromatin, alter gene expression, and participate in normal myeloid differentiation and leukemogenesis. Important advances regarding cell biology, molecular biology, biochemistry, and animal studies of retinoids and myeloid differentiation are reviewed.SummaryGreater understanding of the role of retinoids and their receptors in myeloid cell growth and differentiation provides important insight into normal myelopoiesis. These findings have resulted in successful rational approaches to the treatment of acute leukemia and provide the promise of improved treatments in the near future.