RSS and ROS Sequentially Activated Carbon Monoxide Release for Boosting NIR Imaging-Guided On-Demand Photodynamic Therapy.
RSS and ROS Sequentially Activated Carbon Monoxide Release for Boosting NIR Imaging-Guided On-Demand Photodynamic Therapy.
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DOI：
10.1002/smll.202309529
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发表时间：
2023-12
期刊：
影响因子：
13.3
通讯作者：
Xuemei Dong;Ziwen Zhang;Rongchen Wang;Jie Sun;Chengjun Dong;Lixin Sun;Cai Jia;Xianfeng Gu;Chunchang Zhao
中科院分区：
文献类型：
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作者：
Xuemei Dong;Ziwen Zhang;Rongchen Wang;Jie Sun;Chengjun Dong;Lixin Sun;Cai Jia;Xianfeng Gu;Chunchang Zhao
一氧化碳在抗癌方面显示出巨大的治疗潜力。尤其是多功能CO给药系统的构建，可以促进CO的精确给药，达到理想的治疗效果，但在设计上仍存在很大的挑战。在这项工作中，RSS和ROS顺序激活的CO输送系统的开发，以提高近红外成像引导的按需光动力治疗。该系统由一氧化碳激光器（BOD-CO）和光敏剂（BOD-I）组成。BOD-CO可以被硫化氢特异性激活，同时释放CO供体和NIR荧光，可以识别富含H2 S的肿瘤并指导光治疗，同时在该过程中消耗H2 S。此外，BOD-I在长波长光照射下产生1 O2，从而通过光氧化机制实现PDT和CO的精确局部释放。这种通过RSS和ROS顺序激活CO释放的方式保证了CO输送的安全性和可控性，并有效地避免了输送过程中的泄漏。重要的是，细胞毒性和体内研究表明，CO的释放结合内源性H2 S的消耗放大PDT，实现理想的抗癌效果。据信，这种治疗诊断纳米平台可以为精确的CO递送和涉及气体疗法和PDT的联合治疗提供新的策略。
Carbon monoxide shows great therapeutic potential in anti-cancer. In particular, the construction of multifunctional CO delivery systems can promote the precise delivery of CO and achieve ideal therapeutic effects, but there are still great challenges in design. In this work, a RSS and ROS sequentially activated CO delivery system is developed for boosting NIR imaging-guided on-demand photodynamic therapy. This designed system is composed of a CO releaser (BOD-CO) and a photosensitizer (BOD-I). BOD-CO can be specifically activated by hydrogen sulfide with simultaneous release of CO donor and NIR fluorescence that can identify H2 S-rich tumors and guide light therapy, also depleting H2 S in the process. Moreover, BOD-I generates 1 O2 under long-wavelength light irradiation, enabling both PDT and precise local release of CO via a photooxidation mechanism. Such sequential activation of CO release by RSS and ROS ensured the safety and controllability of CO delivery, and effectively avoided leakage during delivery. Importantly, cytotoxicity and in vivo studies reveal that the release of CO combined with the depletion of endogenous H2 S amplified PDT, achieving ideal anticancer results. It is believed that such theranostic nanoplatform can provide a novel strategy for the precise CO delivery and combined therapy involved in gas therapy and PDT.