Radiation-induced Parotid Gland Changes in Oral Cancer Patients: Correlation Between Parotid Volume and Saliva Production
Radiation-induced Parotid Gland Changes in Oral Cancer Patients: Correlation Between Parotid Volume and Saliva Production
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DOI：
10.1093/jjco/hyp113
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Yamashita, Yasuyuki
中科院分区：
文献类型：
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作者：
Teshima, Keiko;Murakami, Ryuji;Yamashita, Yasuyuki
旨在评估头颈癌患者在放疗（RT）过程中唾液分泌量是否反映了腮腺体积。20 名接受术前化疗放疗的晚期口腔鳞状细胞癌患者接受了 CT 或 MRI 形态学评估以及 Saxon 测试功能评估。对于撒克逊测试，通过在不吞咽的情况下咀嚼之前和之后 2 分钟称重纱布垫来测量唾液产量；正常低值是 2 克。采用配对 t 检验、Spearman 等级相关检验和 Fisher 精确检验比较放疗前和放疗后 2 周的唾液产量和腮腺体积。30 Gy 照射后，平均唾液产量从 4.2 g 下降至 1.0 g（P < 0.01）；唾液产量减少 1.7 至 5.4 克（平均 3.2 克）。平均腮腺体积从 68.2 cm(3) 减少至 47.9 cm(3) (P < 0.01)； RT 后：RT 前腮腺体积比范围为 54% 至 85%（平均 71%）。尽管初始腮腺体积与初始唾液产生量相关（r = 0.47，P = 0.04），但 RT 后没有发现显着相关性（r = 0.08，P = 0.71），并且存在相当大的个体差异。腮腺体积比与唾液减少量呈负相关（r = - 0.79，P < 0.01）。接受放疗的头颈癌患者腮腺体积减少与唾液分泌量减少之间存在相关性。腮腺体积减少可以预测腮腺功能。
To evaluate whether saliva production reflects the parotid volume during the course of radiation therapy (RT) in patients with head-and-neck cancer.Twenty patients with advanced oral squamous cell carcinomas, who were treated with preoperative chemo-RT, underwent morphological assessment with CT or MRI and functional assessment with the Saxon test. For the Saxon test, saliva production was measured by weighing a gauze pad before and 2 min after chewing without swallowing; the low-normal value is 2 g. Saliva production and parotid volumes before and 2 weeks after RT were compared with the paired t-test, the Spearman rank correlation test and the Fisher exact test.After 30 Gy irradiation, mean saliva production was decreased from 4.2 to 1.0 g (P < 0.01); the reduction in saliva production ranged from 1.7 to 5.4 g (mean 3.2 g). The mean parotid volume was decreased from 68.2 to 47.9 cm(3) (P < 0.01); the post-RT:pre-RT parotid volume ratio ranged from 54% to 85% (mean 71%). Although the initial parotid `volume was correlated with initial saliva production (r = 0.47, P = 0.04), no significant correlation was noted after RT (r = 0.08, P = 0.71), and there were considerable individual variations. The parotid volume ratio was inversely correlated with the saliva-reduction amount (r = - 0.79, P < 0.01).There was a correlation between decreased parotid gland volume and decreased saliva production in patients with head-and-neck cancer undergoing RT. Parotid volume reduction may predict parotid gland function.