A non-mitogenic analogue of epidermal growth factor enhances the phosphorylation of endogenous membrane proteins.
A non-mitogenic analogue of epidermal growth factor enhances the phosphorylation of endogenous membrane proteins.
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表皮生长因子的非有丝分裂类似物增强内源性膜蛋白的磷酸化。
DOI：
10.1016/0006-291x(81)91290-0
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发表时间：
1981
影响因子：
3.1
通讯作者：
Schlessinger,J
中科院分区：
文献类型：
--
作者：
Schreiber,AB;Yarden,Y;Schlessinger,J
溴化氰裂解的表皮生长因子(EGF)类似物与EGF受体结合亲和力降低，但不能诱导DNA合成。然而，在相似的受体占有率下，溴化氰裂解的EGF在增强EGF特异性的环核苷酸非依赖性蛋白激酶介导的内源性膜蛋白的磷酸化方面与EGF一样有效。关于EGF诱导的膜蛋白磷酸化的生物学作用有两种可能：1)它与EGF启动DNA合成无关，也不是生长因子的“第二信使”。2)它是EGF激活DNA合成的必要生化信号，但不是充分生化信号。
The cyanogen bromide cleaved analogue of Epidermal Growth Factor (EGF) binds to EGF receptors with reduced affinity but fails to induce DNA synthesis. However, at similar receptor occupancy, cyanogen bromide cleaved EGF is as potent as EGF in enhancing the phosphorylation of endogenous membrane proteins mediated by the EGF specific, cyclic nucleotide independent protein kinase. Two possibilities arise concerning the biological role of the EGF induced membrane protein phosphorylation: 1) it is not related to the triggering of DNA synthesis by EGF and does not serve as “second messenger” for the growth factor. 2) it is a necessary but not sufficient biochemical signal for the activation of DNA synthesis by EGF.