Switchable Cell Trapping Using Superparamagnetic Beads
Switchable Cell Trapping Using Superparamagnetic Beads
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DOI：
10.1109/lmag.2010.2046143
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发表时间：
2010-01-01
影响因子：
1.2
通讯作者：
Haycock, John W.
中科院分区：
文献类型：
--
作者：
Bryan, Matthew T.;Smith, Katherine H.;Haycock, John W.
Ni 81 Fe 19微丝作为定位磁标记神经雪旺细胞的可切换模板的基础进行了研究。磁透射X射线显微镜和微磁学模型表明，磁畴壁可以创建或删除在标记的结构通过施加磁场。含有超顺磁珠的许旺细胞被从畴壁发出的场捕获。这种设计允许许旺细胞在表面上组织起来，形成一个连接的网络，然后在需要时从表面释放出来。由于排列的雪旺细胞可以引导神经再生，该技术对于开发神经胶质细胞-神经元共培养模型在未来周围神经损伤的治疗中具有价值。
Ni81Fe19 microwires are investigated as the basis of a switchable template for positioning magnetically labeled neural Schwann cells. Magnetic transmission X-ray microscopy and micromagnetic modeling show that magnetic domain walls can be created or removed in zigzagged structures by an applied magnetic field. Schwann cells containing superparamagnetic beads are trapped by the field emanating from the domain walls. The design allows Schwann cells to be organized on a surface to form a connected network and then released from the surface if required. As aligned Schwann cells can guide nerve regeneration, this technique is of value for developing glial-neuronal coculture models in the future treatment of peripheral nerve injuries.