International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.
International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.
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DOI：
10.1124/pr.108.00505
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发表时间：
2008-09
影响因子：
21.1
通讯作者：
Sieghart W
中科院分区：
文献类型：
--
作者：
Olsen RW;Sieghart W
在这篇综述中，我们试图总结实验证据的定义本地GABAA受体亚型的存在，并产生一个列表的受体，实际上似乎存在根据目前的知识。这将用于更新国际药理学联合会命名委员会批准的GABAA受体的最新分类（Pharmacol Rev 50：291-313，1998）。GABAA受体是氯离子通道，介导中枢神经系统中快速抑制性神经传递的主要形式。它们是Cys环五聚体配体门控离子通道（LGIC）超家族的成员，并且与该家族的其他成员共享结构和功能同源性。GABAA受体由19个同源亚基基因产物的家族组装而成，并形成许多，大多数是异源寡聚的五聚体。这些受体亚型的性质取决于亚基组成，在地形和个体发育，在细胞和亚细胞定位，在大脑回路和行为中的作用，在他们的调节机制，并在他们的药理学。我们提出了几个标准，它可以适用于所有成员的LGIC超家族，包括一个受体亚型的本地异源寡聚亚型的列表。有了这些标准，我们开发了一个工作GABAA受体列表，目前包括26个成员，但无疑会随着信息的扩展而修改和增长。该列表分为三类天然受体亚型：“已确定”，“高概率存在”和“暂定”。
In this review we attempt to summarize experimental evidence on the existence of defined native GABAA receptor subtypes and to produce a list of receptors that actually seem to exist according to current knowledge. This will serve to update the most recent classification of GABAA receptors (Pharmacol Rev 50:291–313, 1998) approved by the Nomenclature Committee of the International Union of Pharmacology. GABAA receptors are chloride channels that mediate the major form of fast inhibitory neurotransmission in the central nervous system. They are members of the Cys-loop pentameric ligand-gated ion channel (LGIC) superfamily and share structural and functional homology with other members of that family. GABAA receptors are assembled from a family of 19 homologous subunit gene products and form numerous, mostly hetero-oligomeric, pentamers. Such receptor subtypes with properties that depend on subunit composition vary in topography and ontogeny, in cellular and subcellular localization, in their role in brain circuits and behaviors, in their mechanisms of regulation, and in their pharmacology. We propose several criteria, which can be applied to all the members of the LGIC superfamily, for including a receptor subtype on a list of native hetero-oligomeric subtypes. With these criteria, we develop a working GABAA receptor list, which currently includes 26 members, but will undoubtedly be modified and grow as information expands. The list is divided into three categories of native receptor subtypes: “identified,” “existence with high probability,” and “tentative.”
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DOI：
10.1073/pnas.96.17.9891
发表时间：
1999-08-17
影响因子：
11.1
作者：
Bonnert, TP;McKernan, RM;Whiting, PJ
通讯作者：
Whiting, PJ
DOI：
10.1073/pnas.94.20.11031
发表时间：
1997-09-30
影响因子：
11.1
作者：
Belelli, D;Lambert, JJ;Whiting, PJ
通讯作者：
Whiting, PJ
影响因子：
5.3
作者：
Boileau, AJ;Pearce, RA;Czajkowski, C
通讯作者：
Czajkowski, C
影响因子：
4.7
作者：
Boileau, AJ;Baur, R;Czajkowski, C
通讯作者：
Czajkowski, C
影响因子：
7.3
作者：
Brown, N;Kerby, J;Wafford, KA
通讯作者：
Wafford, KA