Protective effect of leaf extract of Ficus hispida Linn. against paracetamol‐induced hepatotoxicity in rats
Protective effect of leaf extract of Ficus hispida Linn. against paracetamol‐induced hepatotoxicity in rats
复制标题
DOI：
10.1002/1099-1573(200009)14:6
复制
发表时间：
2000-09
影响因子：
7.2
通讯作者：
S. Mandal;B. Saraswathi;C. Kumar;Mohana Lakshmi Sabapathi;B. Maiti
中科院分区：
文献类型：
--
作者：
S. Mandal;B. Saraswathi;C. Kumar;Mohana Lakshmi Sabapathi;B. Maiti
对硬毛榕叶的甲醇提取物进行了研究。通过对乙酰氨基酚（750 mg/kg，p.o.）诱导急性肝损伤，评价了桑科（桑科）对大鼠的肝保护活性。口服剂量为400 mg/kg的提取物通过降低血清转氨酶（SGOT和SGPT）、胆红素和碱性磷酸酶（ALP）水平表现出显著的保护作用。通过肝脏切片的组织病理学检查补充这些生化观察结果。提取物的活性也与Liv-52（一种已知的保肝制剂）相当。版权所有© 2000约翰威利父子有限公司。
The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv‐52 a known hepatoprotective formulation. Copyright © 2000 John Wiley & Sons, Ltd.