α2-Adrenergic receptors inhibit catecholamine secretion from bovine adrenal medulla
α2-Adrenergic receptors inhibit catecholamine secretion from bovine adrenal medulla
复制标题
α2-肾上腺素能受体抑制牛肾上腺髓质的儿茶酚胺分泌
DOI：
10.1016/0006-8993(82)90997-0
复制
发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
F. Izumi
中科院分区：
文献类型：
--
作者：
A. Wada;S. Sakurai;Hideyuki Kobayashi;N. Yanagihara;F. Izumi
α-2激动剂可乐定可剂量依赖性地抑制卡莫胆碱诱导的牛肾上腺髓质细胞分泌儿茶酚胺，IC50值为2.8×10−5M。[~3H]可乐定与肾上腺髓质膜结合具有高亲和力和可饱和性的特点。这些结果提示，肾上腺髓质细胞上存在的α_2-肾上腺素能受体对细胞分泌儿茶酚胺有抑制作用。
Catecholamine secretion evoked by carbymlcholine from isolated bovine adrenalinal medullary cells was inhibited byα2-agonist, clonidine, in a dose-dependent manner with IC50value of 2.8 × 10−5M. [3H]Clonidine bound to adrenal medullary membranes with high affinity and saturable characteristics. These results suggest thatα2-adrenergic receptors which exist on adrenal medullary cells have inhibitory effect on the secretion of catecholamine from the cells