Neuronal activity is not required for the initial formation and maturation of visual selectivity
Neuronal activity is not required for the initial formation and maturation of visual selectivity
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DOI：
10.1038/nn.4155
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发表时间：
2015-12-01
影响因子：
25
通讯作者：
Ohki, Kenichi
中科院分区：
文献类型：
--
作者：
Hagihara, Kenta M.;Murakami, Tomonari;Ohki, Kenichi
神经元活动对于早期视觉系统中神经元回路的功能完善是重要的。然而，在大脑皮层的水平上，方向选择性等基本功能的形成是否依赖于神经元的活动仍然是未知的，因为在整个发育过程中很难抑制活动。使用方向选择性形成之前开始的皮质活动的遗传沉默，我们发现，尽管在整个发育过程中自发和视觉诱发的活动受到强烈抑制，但小鼠视觉皮层神经元的方向选择性正常形成和成熟。取向选择性形成后，神经元的择优取向分布发生了重组。我们发现，这个过程需要自发活动，但不是视觉诱发活动。因此，取向选择性的初始形成和成熟在很大程度上独立于神经元的活动，并且初始选择性随后根据神经元的活动而改变。
Neuronal activity is important for the functional refinement of neuronal circuits in the early visual system. At the level of the cerebral cortex, however, it is still unknown whether the formation of fundamental functions such as orientation selectivity depends on neuronal activity, as it has been difficult to suppress activity throughout development. Using genetic silencing of cortical activity starting before the formation of orientation selectivity, we found that the orientation selectivity of neurons in the mouse visual cortex formed and matured normally despite a strong suppression of both spontaneous and visually evoked activity throughout development. After the orientation selectivity formed, the distribution of the preferred orientations of neurons was reorganized. We found that this process required spontaneous activity, but not visually evoked activity. Thus, the initial formation and maturation of orientation selectivity is largely independent of neuronal activity, and the initial selectivity is subsequently modified depending on neuronal activity.