Klotho and the aging process.
Klotho and the aging process.
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DOI：
10.3904/kjim.2011.26.2.113
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Kuro-o M
中科院分区：
文献类型：
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作者：
Kuro-o M
klotho基因最初被鉴定为小鼠中假定的年龄抑制基因，当过度表达时可以延长寿命。当被破坏时，它会诱导类似于人类过早衰老综合症的复杂表型。这个基因是以希腊女神克洛索的名字命名的，克洛索是一位纺织生命之线的女神。从那时起，klotho基因的各种功能方面已经被研究，导致确定了多个新的内分泌轴，调节各种代谢过程和矿物质代谢与衰老之间的意想不到的联系。本文就Klotho的研究进展作一综述，并对Klotho衰老的新机制进行探讨。
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.