CORNEAL DEVELOPMENT .3. THE ROLE OF THE THYROID IN DEHYDRATION AND THE DEVELOPMENT OF TRANSPARENCY
CORNEAL DEVELOPMENT .3. THE ROLE OF THE THYROID IN DEHYDRATION AND THE DEVELOPMENT OF TRANSPARENCY
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DOI：
10.1016/s0014-4835(64)80024-5
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发表时间：
1964-01-01
影响因子：
3.4
通讯作者：
COULOMBRE, JL
中科院分区：
文献类型：
--
作者：
COULOMBRE, AJ;COULOMBRE, JL
在胚胎发育的后半期，鸡胚的角膜失去水分；同时，它传输光的能力也增强了。角膜部分脱水是角膜透明形成的必要条件。它发生在发育的同一时期，当时整个胚胎正在经历相对脱水。这种脱水开始于甲状腺变得活跃，可能是在甲状腺氧化酶的控制下。外源性提供的甲状腺素，在此之前给予，加速了角膜的脱水和透明度的增加。另一方面，抑制甲状腺的2-硫脲嘧啶可以减缓这些变化。在未经治疗的角膜中，以及在经内分泌物质治疗的角膜中，角膜传输光的能力是其水合水平的反比线性函数。
During the second half of embryonic development the cornea of the chick embryo loses water; at the same time its ability to transmit light increases. The partial dehydration of the cornea is a necessary condition for the development of corneal transparency. It occurs during the same period in development when the entire embryo is undergoing a relative dehydration. This dehydration begins as the thyroid gland becomes active, and is probably under the control of thyr ox-ine. Exogenously supplied thyroxine, given prior to this time, accelerates both the dehydration of the cornea and its increase in transparency. On the other hand, 2-thiouracil, which inhibits the thyroid, slows down these changes. In untreated corneas, as well as in corneas treated with endocrine substances, the ability of the cornea to transmit light is an inverse linear function of its level of hydration.