Pretreatment serum hemoglobin level and a preliminary investigation of intratumoral microvessel density in advanced ovarian cancer
Pretreatment serum hemoglobin level and a preliminary investigation of intratumoral microvessel density in advanced ovarian cancer
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DOI：
10.1016/j.ygyno.2004.07.053
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发表时间：
2004-11-01
影响因子：
4.7
通讯作者：
Sismondi, P
中科院分区：
文献类型：
--
作者：
Ferrero, A;Zola, P;Sismondi, P
客观的。本研究的主要目的是评估治疗前血清血红蛋白水平（Hb）对晚期卵巢癌的预后和预测价值。第二个目的是对瘤内微血管密度（IMD）进行初步研究。方法。在 72 名晚期卵巢癌患者中分析了包括 Hb 在内的多种临床病理特征对生存和治疗反应的影响。对 72 名患者中的 25 名患者的肿瘤标本进行了 IMD 评估，以比较三种不同的内皮标志物：抗因子 VIII、抗 CD31 和抗 CD34。在该亚组患者中，对 IMD 的预后和预测价值及其与 Hb 和其他临床病理特征的关系进行了初步分析。结果。在单变量分析中，Hb 大于或等于 12 g/dl 与更好的总生存率显着相关 (P = 0.0181)，并且是多变量分析中唯一的独立预后变量 (P = 0.0160)。 Hb 与无进展生存期 (P = 0.0240) 和治疗完全缓解 (P = 0.016) 直接相关。在 IMD 的初步研究中，所使用的三种内皮标记物之间的平均微血管计数没有显示出任何显着差异，但抗 CD34 显示出更一致的染色反应。 IMD 与治疗完全缓解之间的关系接近统计显着性 (P = 0.05)； Hb 和 IMD 呈负相关（r = -0.47；P = 0.045）。结论。 Hb 对晚期卵巢癌具有预后和预测价值。在我们对有限数量的患者进行的初步研究中，我们发现抗 CD34 是 IMD 测定的最佳标志物，IMD 是治疗完全缓解的可能预测因素，并且 IMD 和 Hb 呈负相关。 (C) 2004 Elsevier Inc. 保留所有权利。
Objective. The primary aim of this study was to evaluate the prognostic and predictive value of pretreatment serum hemoglobin level (Hb) in advanced ovarian cancer; second aim was to perform a preliminary investigation of intratumoral microvessel density (IMD). Methods. The influence on survival and response to treatment of several clinico-pathological features, including Hb, was analyzed in 72 patients with advanced ovarian cancer. IMD was assessed in tumor specimens of 25 of the 72 patients to compare three different endothelial markers: anti-FactorVIII, anti-CD31 and anti-CD34. In this subgroup of patients, a preliminary analysis of the prognostic and predictive value of IMD, and its relationship with Hb and other clinico-pathological features, was performed. Results. Hb greater than or equal to 12 g/dl was significantly associated with a better overall survival in univariate analysis (P = 0.0181) and was the only independent prognostic variable in multivariate analysis (P= 0.0160). Hb was directly related to progression-free survival (P = 0.0240) and complete response to treatment (P = 0.016). In the preliminary investigation of IMD, mean microvessel count did not show any significant difference among the three endothelial markers used, but anti-CD34 revealed a more consistent staining reaction. The relationship between IMD and complete response to treatment was found near to statistical significance (P = 0.05); Hb and IMD were inversely related (r = -0.47; P = 0.045). Conclusions. Hb has a prognostic and predictive value in advanced ovarian cancer. In our preliminary study, which was performed on a limited number of patients, we found anti-CD34 to be an optimal marker for IMD determination, IMD to be a possible predictive factor of complete response to treatment, and IMD and Hb to be inversely related. (C) 2004 Elsevier Inc. All rights reserved.