On the absence or presence of 3D tuned head direction cells in rats: a review and rebuttal.
On the absence or presence of 3D tuned head direction cells in rats: a review and rebuttal.
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关于大鼠中是否存在 3D 调整头部方向细胞：回顾和反驳。
DOI：
10.1152/jn.00475.2019
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发表时间：
2020
影响因子：
2.5
通讯作者：
Shinder,MichaelE
中科院分区：
文献类型：
--
作者：
Taube,JeffreyS;Shinder,MichaelE
空间认知领域的一个主要问题是动物如何表征三维空间。不同的物种已经获得了不同的结果，可能取决于物种是否居住在3D环境或陆地（陆地居住）。头部方向（HD）细胞系统是一个有吸引力的候选人，研究在3D表示。HD细胞的激发是动物在水平面上方向性航向的函数，与动物的位置和正在进行的行为无关。另一个问题涉及高清单元是在3D空间中调谐还是调谐到2D水平面。Shinder和Taube（Shinder ME，Taube JS.J Neurophysiol 121：4-37，2019）通过在3D空间中操纵大鼠的方向，同时监测大鼠前背侧丘脑中经典HD细胞的反应来解决这个问题。他们报告说，HD细胞不显示与俯仰或滚动方向的联合放电。方向特异性放电主要来源于水平半规管信息，重力矢量在影响细胞的放电率和首选放电方向方面发挥了重要作用。Laurens和Angelaki（Laurens J，Angelaki DE.J Neurophysiol 122：1274-1287，2019）通过对Shinder和Taube数据进行数学分析来挑战这一观点，并得出结论，他们不会看到基于实验方法的3D调谐。我们对这些问题进行了历史回顾，然后对实验进行了总结，其中包括额外的分析。然后，我们定义了HD细胞在3D中调谐的意义，并通过反驳Laurens和Angelaki进行的重新分析来完成。
A major question in the field of spatial cognition is how animals represent three-dimensional (3D) space. Different results have been obtained across various species and may depend on whether the species inhabits a 3D environment or is terrestrial (land dwelling). The head direction (HD) cell system is an attractive candidate to study in terms of 3D representations. HD cells fire as a function of the animal’s directional heading in the horizontal plane, independent of the animal’s location and on-going behavior. Another issue concerns whether HD cells are tuned in 3D space or tuned to the 2D horizontal plane. Shinder and Taube (Shinder ME, Taube JS.J Neurophysiol121: 4–37, 2019) addressed this issue by manipulating a rat’s orientation in 3D space while monitoring responses from classic HD cells in the rat anterodorsal thalamus. They reported that HD cells did not display conjunctive firing with pitch or roll orientations. Direction-specific firing was primarily derived from horizontal semicircular canal information and that the gravity vector played an important role in influencing the cell’s firing rate and its preferred firing direction. Laurens and Angelaki (Laurens J, Angelaki DE.J Neurophysiol122: 1274–1287, 2019) challenged this view by performing a mathematical analysis on the Shinder and Taube data and concluded that they would not have seen 3D tuning based on their experimental approach. We provide a historical review of these issues followed by a summary of the experiments, which includes additional analyses. We then define what it means for a HD cell to be tuned in 3D and finish by rebutting the reanalyses performed by Laurens and Angelaki.