Oral pathology in untreated coelic disease
Oral pathology in untreated coelic disease
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DOI：
10.1111/j.1365-2036.2007.03535.x
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发表时间：
2007-12-01
影响因子：
7.6
通讯作者：
Carroccio, A.
中科院分区：
文献类型：
--
作者：
Campisi, G.;Di Liberto, C.;Carroccio, A.
研究背景许多乳糜泻患者的不典型症状仍未得到诊断，目的探讨口腔病变在乳糜泻患者中的发生率，并评估其在乳糜泻诊断中的价值。患者和方法197腹腔疾病患者和413名对照组被招募和口腔examinationwasperformed.Results46的197腹腔疾病患者（23%）被发现有釉质缺损与对照组的9%（P < 0.0001）。26%的儿童乳糜泻患者出现临床延迟性皮疹，而对照组仅为7%（P < 0.0001）。乳糜泻患者口腔软组织病变的发生率为42%，对照组为2%（P < 0.0001）。无麸质饮食1年后，89%的患者复发性阿弗他口炎消失。多因素Logistic回归分析显示，牙釉质缺损（OR = 2.652，CI = 1.427-4.926）和软组织病变（OR = 41.667，CI = 18.868-90.909）对乳糜泻患者的预后影响最大。人工神经网络方法表明，口腔软组织病变的敏感性= 42%，特异性= 98%，测试准确性= 83%in coeliac diseasesdiagnosis.ConclusionsThe口腔软组织病变的总体患病率较高，腹腔疾病患者（42%）比对照组。然而，这些病变对腹腔疾病诊断的阳性预测值较低。
BackgroundMany coeliac disease patients with atypical symptoms remain undiagnosed.AimTo examine the frequency of oral lesions in coeliac disease patients and to assess their usefulness in making coeliac disease diagnosis. Patients and methods One hundred and ninety-seven coeliac disease patients and 413 controls were recruited and the oral examination was performed.ResultsForty-six out of 197 coeliac disease patients (23%) were found to have enamel defects vs. 9% in controls (P < 0.0001). Clinical delayed eruption was observed in 26% of the pediatric coeliac disease patients vs. 7% of the controls (P < 0.0001). The prevalence of oral soft tissues lesions was 42% in the coeliac disease patients and 2% in controls (P < 0.0001). Recurrent aphthous stomatitis disappeared in 89% of the patients after 1 year of gluten-free diet. Multi-logistic analysis selected the following variables as the most meaningful in coeliac disease patients: dental enamel defects (OR = 2.652 CI = 1.427-4.926) and soft tissue lesions (OR = 41.667, CI = 18.868-90.909). Artificial Neural Networks methodology showed that oral soft tissue lesions have sensitivity = 42%, specificity = 98% and test accuracy = 83% in coeliac disease diagnosis.ConclusionsThe overall prevalence of oral soft tissue lesions was higher in coeliac disease patients (42%) than in controls. However, the positive-predictive value of these lesions for coeliac disease diagnosis was low.