Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
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DOI：
10.1016/j.lungcan.2008.03.024
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发表时间：
2008-12-01
期刊：
影响因子：
5.3
通讯作者：
Yock, Torunn I.
中科院分区：
文献类型：
--
作者：
Kozak, Kevin R.;Hong, Theodore S.;Yock, Torunn I.
Cardiotoxicity is a known consequence of thoracic irradiation and there are multiple overlapping risk factors for cardiac disease and thoracic malignancies. In this study, we quantified the impact of thoracic (chemo) radiation on cardiac troponin T (TnT), creatine kinase-myocardial. band (CK-MB) and aminoterminal. pro-brain natriuretic peptide (NT-proBNP). Thirty patients receiving radiation therapy to the thorax with or without concurrent chemotherapy were evaluated. Serum was collected at baseline, 2 weeks into treatment and at the completion of radiation therapy. TnT, CK-MB and NT-proBNP were quantified using commercially available immunoassays. Cardiac dosimetric parameters and clinical. risk factors were examined. In 29 of 30 patients, serum TnT remained undetectable (
