Neurocognitive Complications of HIV Infection in Low-Income Countries.
Neurocognitive Complications of HIV Infection in Low-Income Countries.
复制标题
低收入国家艾滋病毒感染的神经认知并发症。
DOI：
10.1007/7854_2019_92
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发表时间：
2019
影响因子：
--
通讯作者：
Robertson,Kevin
中科院分区：
文献类型：
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作者：
Vecchio,Alyssa;Sacktor,Ned;Saylor,Deanna;Robertson,Kevin
资源有限地区艾滋病毒感染者的神经认知功能障碍方面的信息很少，尽管这些地区的感染负担最重。尽管使用了有效的抗逆转录病毒治疗（ART），但HIV相关的神经认知障碍（HAND）仍然是HIV的常见并发症。HAND是HIV+个体发病的主要原因，估计是全球年轻人中最常见的神经认知障碍形式。这一发现对年轻人在工业、教育和医疗保健发展中的生产力和社会参与产生了重大影响，这在低收入国家尤其重要。建立一个基础设施，以检查在资源有限的设置（RLS）的HIV+个人的神经和神经心理学特征，可以推进在这些地区的HIV-1分支的独特的贡献因素的理解，提高神经监测，探索中枢神经系统HIV水库，并提供预防/干预措施，以帮助管理/改善这些神经和神经心理并发症的关键信息。
There is a paucity of information on neurocognitive dysfunction in individuals with HIV in resource-limited regions, despite the fact that these areas have the greatest burden of infection. HIV-associated neurocognitive disorder (HAND) remains a common complication of HIV despite the use of effective antiretroviral therapy (ART). HAND is a major cause of morbidity of HIV+ individuals and is estimated to be the most prevalent form of neurocognitive impairment worldwide in young adults. This finding has drastic implications for the productivity and social engagement of young adults in the development of industry, education, and healthcare, which is particularly relevant in low-income countries. Building an infrastructure to examine the neurological and neuropsychological characteristics of HIV+ individuals in resource-limited settings (RLS) can advance the understanding of the unique contributing factors of HIV-1 clades in these regions of high prevalence, improve neurological monitoring, explore the CNS HIV reservoir, and provide key information on prevention/interventions to help manage/improve these neurological and neuropsychological complications.