Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results
Polymorphisms of eNOS, catalase, and myeloperoxidase genes in prostate cancer in Turkish men: preliminary results
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DOI：
10.4238/gmr.15038543
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发表时间：
2016-01-01
影响因子：
0.4
通讯作者：
Ozturk, E.
中科院分区：
文献类型：
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作者：
Ceylan, G. G.;Ceylan, C.;Ozturk, E.
前列腺癌(PCa)是欧洲男性最常见的肿瘤类型。遗传和表观遗传因素有助于前列腺癌的发展和进展。在本研究中，我们旨在评估前列腺癌与内皮型一氧化氮合酶(ENOS)、过氧化氢酶(CAT)和髓过氧化物酶(MPO)基因多态性的关系。总共有193名患者参与了这项研究。患者分为三组：前列腺癌(Pca)组78例，良性前列腺增生症(BPH)组40例，对照组男性(75例)。评估的参数包括体重指数(BMI)、吸烟习惯、前列腺特异性抗原(PSA)水平、前列腺标本的Gleason评分以及eNOS-G894T、CAT-262T和MPO G-463T基因的多态性。对照组和患者组的BMI和吸烟状况差异无统计学意义。35.4%的PCa患者CAT-262T基因纯合，是对照组的4.02倍(P=0.006)。ENOS-G894T和MPO G-463T基因多态性在两组间差异均无统计学意义。总之，我们发现过氧化氢酶水平与前列腺癌的诊断和PSA值有关。我们没有发现群体之间在其他多态性方面有任何显著差异，但我们认为，在得出确定的结论之前，可能需要进行进一步的大样本研究。
Prostate cancer (PCa) is the most common type of neoplasm in European males. Genetic and epigenetic factors contribute to PCa development and progression. In this study, we aimed to assess the relationship between PCa and polymorphisms in the genes encoding endothelial nitric oxide synthase (eNOS), catalase (CAT), and myeloperoxidase (MPO). In total, 193 patients were included in the study. Patients were divided into three groups: PCa (78), benign prostate hyperplasia (40), and control males (75). The parameters assessed included body mass index (BMI), smoking habits, presence of prostatism, prostate-specific antigen (PSA) levels, Gleason scores of prostate specimens, as well as polymorphisms in eNOS-G894T, CAT-262T, and MPO G-463T genes. BMI and smoking status of controls and patient groups showed no significant difference. CAT-262T gene polymorphism was found to be homozygous in 35.4% of PCa patients, which was 4.02-fold that in the controls (P = 0.006). There was no statistically significant difference in eNOS-G894T and MPO G-463T gene polymorphisms between any of the groups. In conclusion, we found catalase levels to be associated with PCa diagnosis and PSA value. We did not find any significant differences between groups for other polymorphisms, but we believe that further studies with a large sample size may be needed before drawing definite conclusions.