Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine
Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine
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新型钙拮抗剂尼伐地平治疗老年高血压患者的动态血压监测
DOI：
10.1007/bf00315439
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发表时间：
1991
影响因子：
2.9
通讯作者：
M. Fujishima
中科院分区：
文献类型：
--
作者：
T. Tsuchihashi;A. Tsukashima;K. Matsumura;I. Abe;M. Tominaga;Y. Nakao;K. Kobayashi;M. Fujishima
总结。新开发的钙拮抗剂尼伐地平应用于7例75.6岁的高血压患者，7 ~ 14天后，尼伐地平4mg b.d显著降低24小时平均血压，从169/89 mm Hg降至152/81 mm Hg，脉搏无变化。尼伐地平不影响血压和脉搏的昼夜节律模式。虽然目前的研究是在少数患者中进行的短期初步研究，但结果表明，尼伐地平在不改变老年高血压患者的昼夜节律模式或血压变异性的情况下发挥降压作用。
Summary.A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y.Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mm Hg to 152/81 mm Hg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine.Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.